2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. Anticancer agent 207

Anticancer agent 207 (compound 10b) 是一种有效的抗癌剂。Anticancer agent 207 与 NRAS rG4 结合，KD 值为 2.31 µM。Anticancer agent 207 表现出细胞毒性并降低NRAS蛋白的表达。Anticancer agent 207 显示出抗肿瘤活性。

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Anticancer agent 207 Chemical Structure

Anticancer agent 207 Chemical Structure

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Anticancer agent 207 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anticancer agent 207 (compound 10b) is a potent anticancer agent. Anticancer agent 207 bounds to the NRAS rG4 with a KD value of 2.31 µM. Anticancer agent 207 shows cytotoxicity and decreases the expression of NRAS protein. Anticancer agent 207 shows antitumor activity[1].

IC50 & Target[1]

NRAS rG4

2.31 μM (Kd)

体外研究
(In Vitro)

Anticancer agent 207 (48 h) 对 NRAS 突变黑色素瘤 SK-MEL-2 显示出细胞毒性，IC50 值为 2.0 µM[1]。
Anticancer agent 207 (0, 0.5, 1.0 µM; 72 h) 可降低 NRAS 蛋白的表达[1]。
Anticancer agent 207 (0, 0.13, 0.25 µM; 10 days) 抑制 SK-MEL-2 细胞集落形成[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 207 相关抗体:

Western Blot Analysis[1]

Cell Line: SK-MEL-2 cells
Concentration: 0, 0.5, 1.0 µM
Incubation Time: 72 h
Result: Decreased the expression of NRAS protein in a dose-dependent manner.

Cell Proliferation Assay[1]

Cell Line: MCF-7, HepG2, HL60, A375 cells
Concentration: 0-100 µM
Incubation Time: 48 h
Result: Showed cytotoxicity with IC50s of 4.1, 1.5, 2.7, 4.5 µM for MCF-7, HepG2, HL60, A375 cells, respectively.
体内研究
(In Vivo)

Anticancer agent 207 (1 mg/kg; i.p.; every day for 21 days) 可抑制小鼠肿瘤的体积和重量[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Six-week-old male BALB/C nude mice (SK-MEL-2 xenograft mouse model)[1]
Dosage: 1 mg/kg
Administration: I.p.; every day for 21 days
Result: Suppressed tumor growth in volume and weight in the xenograft mouse model time-dependently.
分子量

494.64

Formula

C29H39FN4O2
Unlabeled CAS

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anticancer agent 207 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 207Anticancer agent207Anticancer agent-207RasmelanomacytotoxicitySK-MEL-2 cellsantitumorNRAS rG4Inhibitorinhibitorinhibit

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