2. Epigenetics PI3K/Akt/mTOR
  3. AMPK mTOR
  4. Asteltoxin

Asteltoxin 细胞外囊泡 (EV) 抑制剂，对线粒体 ATP 合酶和 mTORC1 激活具有抑制作用。

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Asteltoxin Chemical Structure

Asteltoxin Chemical Structure

CAS No. : 79663-49-3

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Asteltoxin 相关抗体

Top Publications Citing Use of Products

查看 AMPK 亚型特异性产品:

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NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1

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mTOR mTORC1 mTORC2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Asteltoxin is an inhibitor for extracellular vesicles (EV), which exhibits inhibitory effects towards mitochondrial ATP synthase and mTORC1 activation[1].

体外研究
(In Vitro)

Asteltoxin (1-100 μg/ml) 抑制 CD63 阳性细胞外囊泡的产生，IC50 为 2.1 μg/ml，并且在 HT29 细胞中没有表现出明显的细胞毒性[1]。
Asteltoxin (1-10 μg/ml) 通过诱导 ATP 下调来激活 AMPK 通路并抑制 mTORC1 通路，激活溶酶体功能并抑制癌细胞 PC-3 分泌细胞外囊泡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Asteltoxin 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: HT-29
Concentration: 1-100 μg/ml
Incubation Time: 24 h
Result: Exhibited cytotoxicity with an IC50 over 100 μg/ml.

Cell Proliferation Assay[1]

Cell Line: PC-3
Concentration: 1-10 μg/ml
Incubation Time: 3 days
Result: Revealed no effect on anchorage-dependent growth of PC-3.

Western Blot Analysis[1]

Cell Line: PC-3
Concentration: 1-10 μg/ml
Incubation Time: 24 h
Result: Increased levels of pAMPK Decreased levels of pS6K and p4E-BP1.
分子量

418.48

Formula

C23H30O7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Asteltoxin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Asteltoxin79663-49-3AMPKmTORAMP-activated protein kinaseMammalian target of RapamycinHT29 colon cancer cellPC-3Inhibitorinhibitorinhibit

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目录号：
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