2. Apoptosis
  3. TNF Receptor
  4. Asunercept

Asunercept  (Synonyms: APG101; CAN008)

目录号: HY-P99445 纯度: 98.13%
COA

摩尔计算器

Asunercept (APG101; CAN008) 是一种靶向 CD95L 的可溶性 CD95-Fc 融合蛋白。Asunercept 通过选择性地与 CD95L 结合，来破坏 CD95/CD95L 的信号传导。Asunercept 可用于多形性胶质母细胞瘤 (GBM)、骨髓增生异常综合征 (MDS) 以及移植物抗宿主病 (GvHD) 的研究。

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Asunercept Chemical Structure

Asunercept Chemical Structure

CAS No. : 1450882-18-4

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规格 价格 是否有货 数量
1 mg ￥5500
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Asunercept 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Asunercept (APG101; CAN008) is a soluble CD95-Fc fusion protein targeting CD95L. Asunercept disrupts CD95/CD95L signaling by selectively binding to CD95L. Asunercept can be used in the research of glioblastoma multiforme (GBM), myelodysplastic syndrome (MDS), and graft-versus-host disease (GvHD)[1][2][3].

IC50 & Target

CD95L[1][2][3].
体外研究
(In Vitro)

Asunercept (APG101; 0-100 µg/mL; preincubation for 30 min) 能特异性中和重组 CD95L 的促凋亡活性[1]。
Asunercept (0.2, 2, 20 µg/mL; 72 h) 能够干扰 CD95 诱导的胶质瘤细胞的迁移/侵袭[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Asunercept 相关抗体:

Apoptosis Analysis[1]

Cell Line: Jurkat A3 cells (APG293-induced)
Concentration: 0-100 µg/mL
Incubation Time: 30 min (preincubation)
Result: Completely neutralized APG293-induced apoptosis.

Cell Invasion Assay[1]

Cell Line: U87-MG cells (CD95L knockdown; APG293-induced)
Concentration: 0.2, 2, 20 µg/mL
Incubation Time: 72 h
Result: Blocked APG293 induced invasion of U87 cells (CD95L knockdown).
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Asunercept 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Asunercept1450882-18-4APG101 CAN008APG 101APG-101CAN008CAN 008CAN-008TNF ReceptorTumor Necrosis Factor ReceptorTNFRJurkat A3 cellsU87-MG cellsAPG293FASLGGBMMDSGvHDInhibitorinhibitorinhibit

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