2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. Atracurium

Atracurium  (Synonyms: BW-33A free acid)

目录号: HY-B0292
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摩尔计算器

Atracurium (BW-33A free acid) 是一种有效的、竞争性的和非去极化的神经肌肉阻滞剂 (neuromuscular blocking)。Atracurium 还是一种 AChR 受体拮抗剂。Atracurium 可诱导支气管收缩和神经肌肉阻滞。Atracurium 促进星形胶质细胞分化[5] 。

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Atracurium Chemical Structure

Atracurium Chemical Structure

CAS No. : 64228-79-1

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Atracurium 的其他形式现货产品:

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Atracurium 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

tracurium (BW-33A free acid) is a potent, competitive and non-depolarizing neuromuscular blocking agent.Atracurium also is an AChR receptor antagonist. Atracurium induces bronchoconstriction and neuromuscular blockade. Atracurium promotes astroglial differentiation[1][2][3][4][5].

体外研究
(In Vitro)

Atracurium (10 µM; 72 h) promotes astroglial but not neuronal differentiation in HSR040622 and HSR040821 cells[4].
Atracurium (10 µM; 48 h) reduces tumor engraftment and increases survival of mice xenotransplanted with ex-vivo treated GSCs[4].
Atracurium (2.4 µM; 120 min) induces a complete fade of the tetanic contraction while only slightly affected the twitch in rat extensor digitorum longus muscle cells[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Atracurium 相关抗体:

Cell Proliferation Assay[4]

Cell Line: glioblastoma stem (GSC) cells
Concentration: 3, 10, 20 µM
Incubation Time: 72 h
Result: Increased the percentage of GFP-positive cells in a dose-dependent manner from 5.3% in DMSO to 15.4%, 81.1%, and 86.8% in 3 μM, 10 μM, and 20 μM, respectively.
体内研究
(In Vivo)

Atracurium (1, 5, 10, 20, 50 mg/kg; i.v.) induces bronchoconstriction in DBA/2 and SJL mice[2].
Atracurium (4.8 mg/kg; i.v.) induces neuromuscular blockade in rats[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 5-12 weeks, 15-20 g male mice[2]
Dosage: 1, 5, 10, 20, 50 mg/kg
Administration: I.v.
Result: Induced bronchoconstriction and Atracurium-induced airway hyperresponsiveness in DBA/2 mice was eliminated in a dose-dependent manner by pretreatment with atropine or pancuronium.
Animal Model: 290 ± 30 g Male Sprague±Dawley rats (60 mg/kg heat-killed Corynebacteriumparvum for i.v.)[3]
Dosage: 4.8 mg/kg
Administration: I.v.
Result: Induced neuromuscular blockade in Corynebacteriumparvum-injected rats.
Clinical Trial
分子量

929.14

Formula

C53H72N2O122+
CAS 号
中文名称

阿曲库铵
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Atracurium 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Atracurium64228-79-1BW-33A阿曲库铵nAChRNicotinic acetylcholine receptorsbronchoconstrictionneuromuscular blockadeinflammatoryHSR-GBM1 GL-2 cellsanticancerGSC cellsInhibitorinhibitorinhibit

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