2. PI3K/Akt/mTOR NF-κB Immunology/Inflammation Apoptosis
  3. PTEN Akt NF-κB Interleukin Related TNF Receptor
  4. Coelonin

Coelonin 是一种具有抗炎活性的二氢菲。Coelonin 可抑制 LPS 诱导的 PTEN 磷酸化。Coelonin 通过负向调节 PI3K/AKT 通路抑制 NF-κB 激活和 p27Kip1 降解。Coelonin 可抑制 IκBα 的磷酸化和降解，增加 IκBα 蛋白的表达。

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Coelonin Chemical Structure

Coelonin Chemical Structure

CAS No. : 82344-82-9

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Coelonin 相关抗体

Top Publications Citing Use of Products

查看 Akt 亚型特异性产品:

查看所有亚型
Akt Akt1 Akt2 Akt3

查看 NF-κB 亚型特异性产品:

查看所有亚型
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Coelonin is a dihydrophenanthrene with anti-inflammation activity. Coelonin inhibits LPS-induced PTEN phosphorylation. Coelonin inhibits NF-κB activation and p27Kip1 degradation by regulating the PI3K/AKT pathway negatively. Coelonin can inhibit IκBα phosphorylation and degradation and increases the expression of IκBα protein[1][2].

IC50 & Target

Akt

 

NF-κB

 

IL-1β

 

IL-6

 

体外研究
(In Vitro)

Coelonin (2.5 μg/mL) 显著降低 NF-κB p65 和 p105/50 磷酸化水平[1]。
Coelonin (0-5 μg/mL, 1.5 h) 剂量依赖性地降低 LPS 诱导的 PTEN、AKT 和 IκBa 磷酸化的增加[1]。
Coelonin (10 和 20 μg/ml) 通过减少炎症因子(包括白细胞介素 6 (IL-6) 和肿瘤坏死因子-α (TNF-α)) 的产生来减轻颗粒物 2.5 (PM2.5) 诱导的炎症< sup>[2].
Coelonin 对 IL-1β、IL-6 和 TNF-α 表达的抑制与 PTEN 无关，而对 p27Kip1 降解的抑制导致细胞周期停滞在 G1 期，这依赖于 PTEN[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Coelonin 相关抗体:

Western Blot Analysis[1]

Cell Line: RAW264.7 cells
Concentration: 0, 1, 2.5, and 5 μg/mL
Incubation Time: 1.5 h
Result: Dose dependently reduced the increase of p65 accumulation in the nucleus induced by LPS. Dose dependently reversed LPS-induced iNOS and COX2 expression. LPS (200 ng/mL) significantly increased the phosphorylation of PTEN, AKT and inhibitor of NF-κB (IκBa), which was dose-dependently reduced by coelonin pre-treatment.
分子量

242.27

Formula

C15H14O3
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Coelonin 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Coelonin82344-82-9PTENAktNF-κBInterleukin RelatedTNF ReceptorPhosphatase and tensin homologMMAC1PKBProtein kinase BNuclear factor-κBNuclear factor-kappaBILTumor Necrosis Factor ReceptorTNFRBletilla striataanti-inflammationcell-cycle arrestRAW264.7 cellanti-silicosishuman lung alveolar epithelialA549 cellsInhibitorinhibitorinhibit

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