2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. Ethybenztropine

Ethybenztropine  (Synonyms: Ponalid; UK 738)

目录号: HY-118406
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摩尔计算器

Ethybenztropine (Ponalid) 是一种毒蕈碱受体 (muscarinic receptor) 阻滞剂。Ethybenztropine 是一种抗胆碱能和抗组胺试剂。

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Ethybenztropine Chemical Structure

Ethybenztropine Chemical Structure

CAS No. : 524-83-4

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Ethybenztropine 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ethybenztropine (Ponalid) is a muscarinic receptor blocker. Ethybenztropine is an anticholinergic and antihistaminergic agent[1].

IC50 & Target

Muscarinic Receptor[1]
体外研究
(In Vitro)

Ethybenztropine (10 μM) inhibits the uptake of 3H-DA in neostriatal slices.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ethybenztropine 相关抗体:
体内研究
(In Vivo)

Ethybenztropine (25 μg, microinjected into mesencephalic NRM) blocks the hypertherrnic response of carbachol microinjection into nucleus raphe median (NRM) of rabbits[1].
Ethybenztropine (30-60 μg/kg, administered by the fourth ventricle) is effective in preventing arrhythmias in dogs[2].
Ethybenztropine (50 mg/kg, i.p.) reduces the catecholamines accumulation in rats[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Dogs with cardiac arrhythmias[2]
Dosage: 30-60 μg/kg
Administration: Administered by the fourth ventricle
Result: Produced slight hypotension (never exceeding a fall of 25 mm Hg) and slight sinus tachycardia.
Converted arrhythmias to sinus rhythms.
分子量

321.46

Formula

C22H27NO
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ethybenztropine 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Ethybenztropine524-83-4Ponalid UK 738UK738UK 738UK-738mAChRMuscarinic acetylcholine receptorCardiacarrhythmiasanticholinergicantihistaminergiccatecholamineInhibitorinhibitorinhibit

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