2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. F15845

F 15845 是一种高效的持久性钠电流阻滞剂。 F 15845 也是一种心脏保护剂，具有抗缺血活性，可在心肌梗塞后发挥短期和长期心脏保护作用。 F 15845 可用于心肌功能障碍的研究。

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F15845 Chemical Structure

F15845 Chemical Structure

CAS No. : 470454-73-0

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F15845 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

F 15845 is a highly effective persistent sodium current blocker. F 15845 also is a cardioprotective agent, has anti-ischemic activity and exerts short- and long-term cardioprotection after myocardial infarction. F 15845 can be used for the research of myocardium functional impairment[1].

体外研究
(In Vitro)

F 15845 (10 nM-10 μM) concentration-dependently reduces veratrine-induced diastolic contracture with an IC50 value of 0.14 μM in isolated atria[1].
F 15845 (0.1-10 μM) preserves viability in isolated cardiomyocytes exposed to lysophosphatidylcholine (LPC)[1].
F 15845 (0.3 μM) significantly counteracts [Na+] increase during no-flow ischemia[1].
F 15845 (0.3 μM, 0-35 min) delays the reduction in [Na+], but marks and maintains upon reperfusion[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

F15845 相关抗体:
体内研究
(In Vivo)

F 15845 (i.v.; 5 mg/kg) exhibits remarkable cardioprotective properties in anesthetized rat[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat[1]
Dosage: 2.5 mg/kg, 5 mg/kg
Administration: intravenously
Result: Significantly reduced infarct size, decreased of troponin I levels and limited the long-term expansion of infarct size.
分子量

375.55

Formula

C20H25NO2S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

F15845 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

F15845470454-73-0F 15845F-15845Sodium ChannelNa channelsNa+ channelssodium currentcardioprotectiveanti-ischemiccardioprotectionmyocardial infarctionmyocardium functional impairmentInhibitorinhibitorinhibit

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目录号：
HY-19463A
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