2. Antibody-drug Conjugate/ADC Related Apoptosis
  3. Antibody-Drug Conjugates (ADCs) Apoptosis
  4. Gemtuzumab ozogamicin

Gemtuzumab ozogamicin  (Synonyms: 吉妥珠单抗奥唑米星)

目录号: HY-109539 纯度: 98.0%
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Gemtuzumab ozogamicin 是一种抗体药物偶联物 (ADC)，由与细胞毒性药物加利车霉素 (HY-19609) 偶联的针对 CD33 的人源化免疫球蛋白 (IgG4) 抗体组成。Calicheamicin 是一种细胞毒性抗生素。Gemtuzumab ozogamicin 可用于急性髓系白血病 (AML) 的研究。

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Gemtuzumab ozogamicin Chemical Structure

Gemtuzumab ozogamicin Chemical Structure

CAS No. : 220578-59-6

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规格 价格 是否有货 数量
100 μg ￥15000
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Gemtuzumab ozogamicin 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Gemtuzumab ozogamicin is an antibody-drug conjugate (ADC) consisting of a humanized immunoglobulin (IgG4) antibody directed against CD33 that is conjugated to the cytotoxic drug Calicheamicin (HY-19609). Calicheamicin is a cytotoxic antibiotic. Gemtuzumab ozogamicin can be used for the research of acute myeloid leukemia (AML)[1][2].

体外研究
(In Vitro)

Gemtuzumab ozogamicin (1-250 ng/mL；72小时) 对 CD33 阳性细胞具有细胞毒性[1]。
Gemtuzumab ozogamicin 是一种 ADC。抗体与 CD33 结合并随后内化后，Calicheamicin 主要通过诱导 DNA 损伤和随后的细胞凋亡来介导对 CD33 阳性骨髓细胞的细胞毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Gemtuzumab ozogamicin 相关抗体:

Cell Viability Assay[1]

Cell Line: CD33-positive and CD33-deficient cells (HL60, HL60R, Kasumi-1, MV4-11, MV4-11R, primary CD34-positive HSPCs and primary AML blasts)
Concentration: 0, 1, 5, 10, 25, 50, 100, 250 ng/mL
Incubation Time: 72 hours
Result: Wildtype HL60 exhibited the highest sensitivity to GO (IC50=1.37 ng/mL), and almost all HL60 cells died at 5 ng/mL concentration.
HL60R, Kasumi-1, MV4-11 and MV4-11R showed similar sensitivity, with IC50s of 2.28, 3.19, 3.63 and 5.36 ng/mL, respectively.
IC50 in CD33-negative HL60R, Kasumi-1, MV4-11 and MV4-11R cells also increased significantly to 95.53, 50.78, 72.74 and 66.8 ng/mL, respectively.
Clinical Trial
CAS 号
性状

固体

颜色

White to off-white

中文名称

吉妥珠单抗奥唑米星
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

纯度 & 产品资料

纯度: 98.0%

COA (150 KB)

产品使用指南 (1538 KB)
参考文献

Gemtuzumab ozogamicin 相关分类

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Keywords:

Gemtuzumab ozogamicin220578-59-6吉妥珠单抗奥唑米星Antibody-Drug Conjugates (ADCs)ApoptosisAntibody-Drug ConjugatesIgG4CD33antibioticacute myeloid leukemiaAMLInhibitorinhibitorinhibit

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