Rorc - RAR-related orphan receptor gamma Gene

中文名称：RAR 相关孤儿受体 γ

种属: Mus musculus

同用名: TOR; Thor; Nr1f3; RORgamma

关于 Rorc

功能概要

该基因编码的蛋白可启动 DNA 结合转录因子活性、RNA 聚合酶 II 特异性和转录共激活因子结合活性。参与多个过程，包括造血或淋巴器官发育；胸腺细胞凋亡过程的负调控；和基因表达的调控。作用于造血或淋巴器官发育的上游或内部；蛋白质磷酸化；和调节 γ-δ T 细胞分化。位于质膜和细胞核的外侧。以多种结构表达，包括中枢神经系统；泌尿生殖系统；淋巴系统；感觉器官；和甲状腺。用于研究干燥综合征。该基因与免疫缺陷 42 相关的人类直向同源基因。与人类 RORC（RAR 相关孤儿受体 C）直向同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables DNA-binding transcription factor activity, RNA polymerase II-specific and transcription coactivator binding activity. Involved in several processes, including hematopoietic or lymphoid organ development; negative regulation of thymocyte apoptotic process; and regulation of gene expression. Acts upstream of or within hematopoietic or lymphoid organ development; protein phosphorylation; and regulation of gamma-delta T cell differentiation. Located in external side of plasma membrane and nucleus. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system; sensory organ; and thyroid gland. Used to study Sjogren's syndrome. Human ortholog(s) of this gene implicated in immunodeficiency 42. Orthologous to human RORC (RAR related orphan receptor C). [provided by Alliance of Genome Resources, Apr 2022]