GGT5 - gamma-glutamyltransferase 5 Gene

中文名称：γ-谷氨酰转移酶 5

种属: Homo sapiens

同用名: GGL; GGT 5; GGTLA1; GGT-REL

关于 GGT5

功能概要

该基因是γ-谷氨酰转肽酶基因家族的成员，一些报道表明它能够切割谷胱甘肽的γ-谷氨酰部分。由该基因编码的蛋白质被合成为单一的、无催化活性的多肽，在转录后加工形成重亚基和轻亚基，催化活性包含在小亚基内。编码的酶能够将白三烯 C4 转化为白三烯 D4，但与 γ-谷氨酰转肽酶相比似乎具有不同的底物特异性。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2014 年 10 月]

This gene is a member of the gamma-glutamyl transpeptidase gene family, and some reports indicate that it is capable of cleaving the gamma-glutamyl moiety of glutathione. The protein encoded by this gene is synthesized as a single, catalytically-inactive polypeptide, that is processed post-transcriptionally to form a heavy and LIGHT subunit, with the catalytic activity contained within the small subunit. The encoded Enzyme is able to convert leukotriene C4 to leukotriene D4, but appears to have distinct substrate specificity compared to gamma-glutamyl transpeptidase. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]