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  2. Hdac4 - histone deacetylase 4 Gene

Hdac4 - histone deacetylase 4 Gene

中文名称:组蛋白脱乙酰酶 4

种属: Rattus norvegicus

基因 ID: 363287 | 基因类型: protein coding

关于 Hdac4

Primary_assembly 9: 92,507,611-92,750,164 reverse strand.mRatBN7.2:CM026982.1

This gene has 2 transcripts (splice variants), 263 orthologues, 12 paralogues and is associated with 40 phenotypes. Biased expression in Adrenal (RPKM 6.6), Thymus (RPKM 53.6) and 9 other tissues.

功能概要

该基因编码的蛋白可启动启动子特异性染色质结合活性。涉及多个过程,包括细胞对机械刺激的反应;对甲状旁腺激素刺激的细胞反应;和 lamellipodium 组件的正向调节。位于胞质溶胶中;核;和肌节。部分含蛋白质复合物。大脑中动脉梗死的生物标志物。该基因的人类直系同源物与共济失调毛细血管扩张有关;染色体 2q37 缺失综合征;饮食失调;和视网膜变性。与人类 HDAC4(组蛋白脱乙酰酶 4)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables promoter-specific chromatin binding activity. Involved in several processes, including cellular response to mechanical stimulus; cellular response to parathyroid hormone stimulus; and positive regulation of lamellipodium assembly. Located in cytosol; nucleus; and sarcomere. Part of protein-containing complex. Biomarker of middle cerebral artery infarction. Human ortholog(s) of this gene implicated in ataxia telangiectasia; chromosome 2q37 deletion syndrome; eating disorder; and retinal degeneration. Orthologous to human HDAC4 (histone deacetylase 4). [provided by Alliance of Genome Resources, Apr 2022]

Hdac4 基因产物(1)

mRNA Protein Name
NM_053449.1 NP_445901.1 histone deacetylase 4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables promoter-specific chromatin binding IDA
IDA: 通过直接分析推断
21586557 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
21464227 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in A band IDA
IDA: 通过直接分析推断
18250163 RGD
located in Z disc IDA
IDA: 通过直接分析推断
18250163 RGD
part of protein-containing complex IDA
IDA: 通过直接分析推断
22360269 RGD
located in sarcomere IDA
IDA: 通过直接分析推断
18250163 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Hdac4 蛋白结构

ClassIIa_HDAC4_Gln-rich-N

ClassIIa_HDAC4_Gln-rich-N: cd10162 (98 - 159)

HDAC4

HDAC4: cd10006 (660 - 1068)

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  • 1096 a.a.
蛋白主名 其他名称

histone deacetylase 4

HD4

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Hdac4 NCBI NCBI:9759