2. Gene
  3. Hdac4 - histone deacetylase 4 Gene

Hdac4 - histone deacetylase 4 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：组蛋白脱乙酰酶 4

种属: Rattus norvegicus

基因 ID: 363287 | 基因类型: protein coding

关于 Hdac4

Primary_assembly 9: 92,507,611-92,750,164 reverse strand.mRatBN7.2:CM026982.1

This gene has 2 transcripts (splice variants), 263 orthologues, 12 paralogues and is associated with 40 phenotypes. Biased expression in Adrenal (RPKM 6.6), Thymus (RPKM 53.6) and 9 other tissues.

功能概要

该基因编码的蛋白可启动启动子特异性染色质结合活性。涉及多个过程，包括细胞对机械刺激的反应；对甲状旁腺激素刺激的细胞反应；和 lamellipodium 组件的正向调节。位于胞质溶胶中；核;和肌节。部分含蛋白质复合物。大脑中动脉梗死的生物标志物。该基因的人类直系同源物与共济失调毛细血管扩张有关；染色体 2q37 缺失综合征；饮食失调；和视网膜变性。与人类 HDAC4（组蛋白脱乙酰酶 4）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables promoter-specific chromatin binding activity. Involved in several processes, including cellular response to mechanical stimulus; cellular response to parathyroid hormone stimulus; and positive regulation of lamellipodium assembly. Located in cytosol; nucleus; and sarcomere. Part of protein-containing complex. Biomarker of middle cerebral artery infarction. Human ortholog(s) of this gene implicated in ataxia telangiectasia; chromosome 2q37 deletion syndrome; eating disorder; and retinal degeneration. Orthologous to human HDAC4 (histone deacetylase 4). [provided by Alliance of Genome Resources, Apr 2022]

Hdac4 基因产物(1)

mRNA Protein Name
NM_053449.1 NP_445901.1 histone deacetylase 4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables promoter-specific chromatin binding IDA
IDA: 通过直接分析推断
21586557 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
21464227 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to mechanical stimulus IEP
IEP: 通过表达模式推断
19261284 RGD
involved in cellular response to parathyroid hormone stimulus IEP
IEP: 通过表达模式推断
20097749 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: 通过表达模式推断
22389387 RGD
involved in positive regulation of lamellipodium assembly IMP
IMP: 通过突变表型推断
24166750 RGD
involved in positive regulation of male mating behavior IMP
IMP: 通过突变表型推断
21586557 RGD
involved in positive regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
23925573 RGD
involved in positive regulation of reactive oxygen species biosynthetic process IMP
IMP: 通过突变表型推断
24166750 RGD
involved in positive regulation of smooth muscle cell migration IMP
IMP: 通过突变表型推断
24166750 RGD
involved in positive regulation of smooth muscle cell proliferation IMP
IMP: 通过突变表型推断
24166750 RGD
involved in response to alcohol IEP
IEP: 通过表达模式推断
26509893 RGD
involved in response to xenobiotic stimulus IDA
IDA: 通过直接分析推断
16767219 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in A band IDA
IDA: 通过直接分析推断
18250163 RGD
located in Z disc IDA
IDA: 通过直接分析推断
18250163 RGD
part of protein-containing complex IDA
IDA: 通过直接分析推断
22360269 RGD
located in sarcomere IDA
IDA: 通过直接分析推断
18250163 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Hdac4 蛋白结构

ClassIIa_HDAC4_Gln-rich-N

ClassIIa_HDAC4_Gln-rich-N: cd10162 (98 - 159)

HDAC4

HDAC4: cd10006 (660 - 1068)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1096 a.a.
蛋白主名 其他名称

histone deacetylase 4

HD4

相关产品

Approval
生物活性分子 (3)
目录号 产品名 作用方式
纯度 是否罕见病
HY-15149 Romidepsin Inhibitor 99.98% 否
HY-14842 Givinostat Inhibitor 98.67% 是
HY-13322 Pracinostat Inhibitor 99.80% 是
Clinical Phase
生物活性分子 (8)
目录号 产品名 作用方式
纯度 Phase
HY-10528 Tasquinimod Modulator 99.94% Phase 3
HY-14842B Givinostat hydrochloride monohydrate Inhibitor 98.06% Phase 3
HY-14842A Givinostat hydrochloride Inhibitor 98.06% Phase 3
HY-16026 Ricolinostat Inhibitor 99.83% Phase 2
HY-15433 Quisinostat Inhibitor 99.71% Phase 2
HY-13522 Fimepinostat Inhibitor 99.95% Phase 2
HY-15433A Quisinostat dihydrochloride Inhibitor 99.05% Phase 2
HY-10223 CUDC-101 Inhibitor 99.05% Phase 1
Pre-clinical Phase
生物活性分子 (44)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-18361 TMP195 Inhibitor 99.82% 否
HY-18998 LMK-235 Inhibitor 99.61% 否
HY-13428 Tubacin Inhibitor 99.54% 否
HY-18360 TMP269 Inhibitor 98.16% 否
HY-16699 Nexturastat A Inhibitor 98.28% 否
HY-119939 CHDI-390576 Inhibitor 98.10% 否
HY-115475 SW-100 Inhibitor 99.93% 否
HY-123295 HDAC3-IN-T247 Inhibitor 98.91% 否
HY-19350 BML-210 Inhibitor 98.04% 否
HY-149285 NT160 Inhibitor 99.58% 否
HY-12954 PTACH Inhibitor 99.65% 否
HY-146153 HDAC-IN-40 Inhibitor 98.71% 否
HY-150109 Purinostat mesylate Inhibitor 99.45% 否
HY-117554 BRD9757 Inhibitor 99.75% 否
HY-135714 Bavarostat Inhibitor 99.51% 否
HY-146678 HDAC6-IN-5 Inhibitor / 否
HY-146679 HDAC6-IN-6 Inhibitor / 否
HY-161778 ZG-126 Inhibitor / 否
HY-172159 FF2039 Inhibitor / 否
HY-146684 HDAC-IN-36 Inhibitor / 否
HY-174302 PIM-1/HDAC-IN-2 Inhibitor / 否
HY-149372 HDAC6-IN-17 Inhibitor / 否
HY-151263 G4/HDAC-IN-1 Inhibitor / 否
HY-151897 HDAC-IN-49 Inhibitor / 否
HY-163803 CM-444 Inhibitor / 否
HY-15144B (S)-Trichostatin A Inhibitor / 否
HY-150595 HDAC6-IN-10 Inhibitor / 否
HY-150503 KH-259 Inhibitor / 否
HY-157740 XSJ-10 Inhibitor / 否
HY-146159 PI3K/HDAC-IN-2 Inhibitor / 否
HY-162630 HDAC6-IN-44 Inhibitor / 否
HY-149721 HDAC4-IN-1 Inhibitor / 否
HY-170379 HDAC-IN-84 Inhibitor / 否
HY-169400 HDACs/EZH2-IN-1 Inhibitor / 否
HY-147934 HDAC8-IN-3 Inhibitor / 否
HY-152226 MC2590 Inhibitor 98.71% 否
HY-151896 HDAC6-IN-14 Inhibitor / 否
HY-124946 C1A Inhibitor / 否
HY-149283 JAK/HDAC-IN-2 Inhibitor / 否
HY-149208 HDAC-IN-53 Inhibitor / 否
HY-163143 HDAC8-IN-6 Inhibitor / 否
HY-152225 MC2625 Inhibitor / 否
HY-143233 PIM-1/HDAC-IN-1 Inhibitor / 否
HY-148624 CHDI-00484077 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Hdac4 NCBI NCBI:9759
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