2. Gene
  3. NARS1 - asparaginyl-tRNA synthetase 1 Gene

NARS1 - asparaginyl-tRNA synthetase 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：天冬酰胺-tRNA 合成酶 1

种属: Homo sapiens

同用名: NARS; ASNRS; NEDMILG; NEDMILEG

基因 ID: 4677 | 基因类型: protein coding

关于 NARS1

Cytogenetic location: 18q21.31 Genomic coordinates (GRCh38): 18:57,600,656-57,621,836 (from NCBI)

This gene has 12 transcripts (splice variants), 233 orthologues, 4 paralogues and is associated with 4 phenotypes. Ubiquitous expression in thyroid (RPKM 64.3), kidney (RPKM 57.0) and 25 other tissues.

功能概要

氨酰-tRNA 合成酶是一类用同源氨基酸给 tRNA 充电的酶。天冬酰胺酰-tRNA 合成酶定位于细胞质，属于 tRNA 合成酶的 II 类家族。 N 末端结构域代表真核天冬酰胺酰-tRNA 合成酶的特征序列。[RefSeq 提供，2008 年 7 月]

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate Amino acids. Asparaginyl-tRNA synthetase is localized to the cytoplasm and belongs to the class II family of tRNA synthetases. The N-terminal domain represents the signature sequence for the eukaryotic asparaginyl-tRNA synthetases. [provided by RefSeq, Jul 2008]

NARS1 基因产物(1)

mRNA Protein Name
NM_004539.4 NP_004530.1 asparagine--tRNA ligase, cytoplasmic

NARS1 蛋白结构

tRNA_anti-codon

tRNA_anti-codon: OB-fold nucleic acid binding domain (128 - 208)

tRNA-synt_2

tRNA-synt_2: tRNA synthetases class II (D, K and N) (227 - 542)

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  • 500
  • 548 a.a.
蛋白主名 其他名称

asparagine--tRNA ligase, cytoplasmic

asparagine tRNA ligase 1, cytoplasmic

重组 NARS1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74738 NARS Protein, Human (sf9, His) O43776 (M1-P548) ≥95%

关联疾病

疾病名称 别名
Neurodevelopmental Disorder With Microcephaly, Impaired Language, Epilepsy, And Gait Abnormalities

NEDMILEG

Neurodevelopmental Disorder With Microcephaly, Impaired Language, Epilepsy, And Gait Abnormalities, Autosomal Dominant
Neurodevelopmental Disorder With Microcephaly, Impaired Language, And Gait Abnormalities

NEDMILG

Neurodevelopmental Disorder With Microcephaly, Impaired Language, And Gait Abnormalities, Autosomal Recessive
Mitochondrial Complex I Deficiency, Nuclear Type 35

MC1DN35

Mitochondrial Complex 1 Deficiency, Nuclear Type 35

Nuclear Type Mitochondrial Complex I Deficiency 35
Myositis

Idiopathic Inflammatory Myopathy

Idiopathic Inflammatory Myositis

Iim

Imm

Idiopathic Inflammatory Myopathies

Myopathy, Familial Idiopathic Inflammatory

Inflammatory Disorder Of Muscle

Idiopathic Inflammatory Myopathy, Familial

Inflammatory Myopathy, Idiopathic

Myopathies Idiopathic Inflammatory

Familial Idiopathic Inflammatory Myopathy
Interstitial Lung Disease

Ild

Lung Diseases, Interstitial

Lung Diseases Interstitial

Interstitial Lung Diseases
Lung Disease

Lung Diseases

Disorder Of Lung

Abnormality Of The Lung
Deafness, Autosomal Recessive 94

DFNB94

Autosomal Recessive Nonsyndromic Deafness 94

Autosomal Recessive Deafness 94

Deafness, Autosomal Recessive, 94
Filarial Elephantiasis

Lymphatic Filariasis

Elephantiasis

Filariasis

Bancroftian Elephantiasis

Bancroftian Filarial Chyluria

Elephantiasis Of Eyelid

Bancroftian Filariasis

Elephantitis

Malayi Tropical Eosinphilia

Wuchereria Bancrofti Infection

Wuchereriasis

Elephantiasis, Filarial

Filarial Elephantiases

Infection By Wuchereria Bancrofti

Filarial Lymphangitis

Tropical Elephantiasis

Filarial Chylocele
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09036 NARS1 Human Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus NARS1 RGD RGD:1307238
Mus musculus NARS1 MGD MGI:1917473
Felis catus NARS1 VGNC VGNC:68416
Macaca mulatta NARS1 VGNC VGNC:75132
Canis familiaris NARS1 VGNC VGNC:43625
Others NARS1 NCBI
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