NARS 蛋白, Human (sf9, His)

NARS, a pivotal enzyme in protein synthesis, plays a crucial role in the attachment of asparagine to tRNA(Asn) through a meticulously orchestrated two-step process. Initially, asparagine undergoes activation by ATP, resulting in the formation of Asn-AMP. Subsequently, this activated asparagine is diligently transferred to the acceptor end of tRNA(Asn). Beyond its fundamental involvement in protein synthesis, NARS assumes an additional role as a signaling molecule capable of inducing the migration of CCR3-expressing cells. The multifaceted functions of NARS extend to the realm of developmental processes, where it emerges as an indispensable contributor to the proper proliferation of radial glial cells, particularly in the development of the cerebral cortex. The intricate interplay of NARS in both protein synthesis and cellular signaling underscores its significance in fundamental biological processes. NARS Protein, Human (sf9, His) is the recombinant human-derived NARS protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of NARS Protein, Human (sf9, His) is 548 a.a., with molecular weight of ~65.3 kDa.

NARS 是蛋白质合成中的关键酶，通过精心策划的两步过程，在天冬酰胺与 tRNA (Asn) 的附着中发挥着至关重要的作用。最初，天冬酰胺被 ATP 激活，形成 Asn-AMP。随后，这种活化的天冬酰胺被努力转移到 tRNA (Asn) 的受体末端。除了在蛋白质合成中的基本参与之外，NARS 还承担了作为能够诱导 CCR3 表达细胞迁移的信号分子的额外作用。 NARS 的多方面功能延伸到发育过程领域，它成为放射状胶质细胞正常增殖不可或缺的贡献者，特别是在大脑皮层的发育中。 NARS 在蛋白质合成和细胞信号传导中复杂的相互作用强调了其在基本生物过程中的重要性。

Human

Sf9 insect cells

N-His

O43776 (M1-P548)

4677  [NCBI]

Approximately 65.3 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.