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  3. PRCP - prolylcarboxypeptidase Gene

PRCP - prolylcarboxypeptidase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：脯氨酰羧肽酶

种属: Homo sapiens

同用名: PCP; HUMPCP

基因 ID: 5547 | 基因类型: protein coding

关于 PRCP

Cytogenetic location: 11q14.1 Genomic coordinates (GRCh38): 11:82,822,936-82,901,644 (from NCBI)

This gene has 37 transcripts (splice variants), 199 orthologues and 2 paralogues. Ubiquitous expression in placenta (RPKM 42.6), urinary bladder (RPKM 37.6) and 25 other tissues.

功能概要

该基因编码丝氨酸外肽酶肽酶 S28 家族的成员。编码的前原蛋白经过蛋白水解处理以产生成熟的溶酶体脯氨酰羧肽酶。该酶可裂解肽中与脯氨酸相连的 C 末端氨基酸，例如血管紧张素 II、III 和 des-Arg9-缓激肽。裂解发生在酸性 pH 值下，但酶活性在中性 pH 值下与一些底物保持一致。该酶已被证明是细胞基质相关前激肽释放酶的激活剂。血管紧张素 II (该酶的底物之一) 在调节血压和电解质平衡方面的重要性表明该基因可能与原发性高血压有关。已在 2 号染色体上鉴定出该基因的假基因。可变剪接导致多个转录物变体，其中至少一个变体编码一种经过蛋白水解处理的亚型。[RefSeq 提供，2016 年 1 月]

This gene encodes a member of the peptidase S28 family of serine exopeptidases. The encoded preproprotein is proteolytically processed to generate the mature lysosomal prolylcarboxypeptidase. This Enzyme cleaves C-terminal Amino acids linked to proline in Peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the Enzyme activity is retained with some substrates at neutral pH. This Enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this Enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. A pseudogene of this gene has been identified on chromosome 2. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

PRCP 基因产物(3)

mRNA Protein Name
NM_001319214.2 NP_001306143.1 lysosomal Pro-X carboxypeptidase isoform 3
NM_005040.4 NP_005031.1 lysosomal Pro-X carboxypeptidase isoform 1 preproprotein
NM_199418.4 NP_955450.2 lysosomal Pro-X carboxypeptidase isoform 2 precursor

PRCP 蛋白结构

Peptidase_S28

Peptidase_S28: Serine carboxypeptidase S28 (55 - 475)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 496 a.a.
蛋白主名 其他名称

lysosomal Pro-X carboxypeptidase

angiotensinase C

重组 PRCP 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7668 PRCP Protein, Human (HEK293, His) P42785 (L22-H496) ≥95%

关联疾病

疾病名称 别名
Pyruvate Kinase Deficiency Of Red Cells

Pyruvate Kinase Deficiency

Pk Deficiency

Pyruvate Kinase Deficiency Of Erythrocyte

Hemolytic Anemia Due To Red Cell Pyruvate Kinase Deficiency

Pyruvate Kinase Deficiency Of Erythrocytes

Pkd

PKRD

Hereditary Non-Spherocytic Hemolytic Anemia Due To Pyruvate Kinase Deficiency

Hnsha

Pyruvate Kinase-Deficient Hemolytic Anemia

Red Cell Pyruvate Kinase Deficiency

Deficiency Of Pyruvate Kinase

Anemia, Hemolytic, Congenital Nonspherocytic
High Molecular Weight Kininogen Deficiency

HMWK DEFICIENCY

Fitzgerald Trait

Congenital High-Molecular-Weight Kininogen Deficiency

Flaujeac Factor Deficiency

Kininogen Deficiency, High Molecular Weight

Kininogen Deficiency

Hmwk

High-Molecular-Weight Kininogen Deficiency, Congenital
Congenital Nonspherocytic Hemolytic Anemia

Hereditary Non-Spherocytic Hemolytic Anemia

Hereditary Nonspherocytic Hemolytic Anemia

Anemia, Hemolytic, Congenital Nonspherocytic

Congenital Nonspherocytic Hemolytic Anaemia

Hereditary Nonspherocytic Hemolytic Anaemia

Hnsha
Hereditary Angioedema

Hereditary Angioneurotic Edema

Hereditary Angioedema Type 1

Hane

Angioedema, Hereditary

Hae

Angioedemas, Hereditary

Deficiency Of C1 Esterase Inhibitor

C1 Esterase Inhibitor Deficiency

C1 Inhibitor Deficiency

Familial Angioneurotic Edema

Hereditary Bradykinine-Induced Angioedema

Hereditary Non Histamine-Induced Angioedema

Hae 1

Hae-I

Hereditary Angioneurotic Edema Type 1

Hereditary C1 Esterase Inhibitor Deficiency - Deficient Factor

Hereditary Angioedema Types I And Ii

Hereditary Angioneurotic Oedema

Familial Angioedema

Hae - [Hereditary Angioneurotic Oedema]

Bannister Disease, Hereditary

Quincke Disease Or Oedema

Hereditary Quincke Oedema
Hypertension, Essential

Essential Hypertension

Hypertension

High Blood Pressure

Hypertension, Essential, Susceptibility To

Hypertensive Disease

Primary Hypertension

EHT

Hypertension, Salt-Sensitive Essential, Susceptibility To

Hyperpiesia

Idiopathic Hypertension

Hypertensive Disorder

Hypertension, Essential, Susceptibility To, 3

Hypertension, Essential 3

Hypertension, Essential, Salt-Sensitive

Hypertension, Essential, Susceptibility To, 6

Hypertension, Essential 6

Hypertension, Salt-Sensitive Essential

Hypertension, Susceptibility To

Hypertension, Essential, Susceptibility To, 4

Hypertension, Essential 4

Hypertension, Essential, Susceptibility To, 2

Hypertension, Essential 2

Hypertension, Essential, Susceptibility To, 1

Hypertension, Essential 1

Hypertension, Essential, Susceptibility To, 5

Hypertension, Essential 5

Htn

Vascular Hypertensive Disorder

Systemic Primary Arterial Hypertension

Hbp - [High Blood Pressure]

Systemic Arterial Hypertensive Disorder

Elevated Blood Pressure

Arterial Hypertension Nos

Hypertension Nos

Benign Hypertension

Systemic Arterial Hypertension

Systemic Hypertension

Artery Htn

Benign Htn

Vascular Htn

Vascular Hypertension

Cholesterol Hypertension

Cholesterol Htn

Idiopathic Htn

Malignant Hypertension

Malignant Htn

Raised Blood Pressure

Cardiovascular Hypertension

Primary Htn - [Hypertension]

High Arterial Tension

High Blood Pressure Disorder

Ht - [Hypertension]

Htn - [Hypertension]

Hypertensive Vascular Disease

Hypertensive Vascular Degeneration
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11058 PRCP Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus PRCP VGNC VGNC:33287
Felis catus PRCP VGNC VGNC:69032
Canis familiaris PRCP VGNC VGNC:44943
Macaca mulatta PRCP VGNC VGNC:76390
Rattus norvegicus PRCP RGD RGD:1307842
Mus musculus PRCP MGD MGI:1919711
Others PRCP NCBI
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