IL36G - interleukin 36 gamma Gene

中文名称：白细胞介素 36 γ

种属: Homo sapiens

同用名: IL1E; IL1F9; IL1H1; IL-1F9; IL-1H1; IL1RP2; IL-1RP2

基因 ID: 56300 | 基因类型: protein coding

关于 IL36G

Cytogenetic location: 2q14.1 Genomic coordinates (GRCh38): 2:112,978,006-112,985,658 (from NCBI)

This gene has 3 transcripts (splice variants), 230 orthologues and 7 paralogues. Biased expression in skin (RPKM 3.5) and esophagus (RPKM 1.0).

功能概要

该基因编码的蛋白质是白介素 1 细胞因子家族的成员。这种细胞因子的活性由白细胞介素 1 受体样 2 (IL1RL2/IL1R-rp2) 介导，并被白细胞介素 1 家族成员 5 (IL1F5/IL-1 delta) 特异性抑制。据报道，干扰素-γ、肿瘤坏死因子-α 和白细胞介素 1、β (IL1B) 可刺激角质形成细胞中这种细胞因子的表达。这种细胞因子在角质形成细胞中的表达也可以通过接触性超敏反应或单纯疱疹病毒感染来诱导。该基因和其他八个白细胞介素 1 家族基因在 2 号染色体上形成一个细胞因子基因簇。[RefSeq 提供，2019 年 5 月]

The protein encoded by this gene is a member of the interleukin 1 cytokine family. The activity of this cytokine is mediated by interleukin 1 receptor-like 2 (IL1RL2/IL1R-rp2), and is specifically inhibited by interleukin 1 family, member 5 (IL1F5/IL-1 delta). Interferon-gamma, tumor necrosis factor-alpha and interleukin 1, beta (IL1B) are reported to stimulate the expression of this cytokine in keratinocytes. The expression of this cytokine in keratinocytes can also be induced by a contact hypersensitivity reaction or herpes simplex virus Infection. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, May 2019]

IL36G 基因产物(2)

mRNA	Protein	Name
NM_001278568.2	NP_001265497.1	interleukin-36 gamma isoform 2
NM_019618.4	NP_062564.1	interleukin-36 gamma isoform 1

IL36G 蛋白结构

IL1

0
100
169 a.a.

蛋白主名

其他名称

interleukin-36 gamma

IL-1 related protein 2

重组 IL36G 蛋白

目录号	产品名	蛋白编号	纯度
HY-P70670	IL-36 gamma/IL-1F9 Protein, Human (152a.a)	Q9NZH8-1 (S18-D169)	≥95%
HY-P71863	IL-36 gamma/IL-1F9 Protein, Human (169a.a)	Q9NZH8 (M1-D169)	≥95%
HY-P71864	IL36G, Human (152a.a)	Q9NZH8 (S18-D169)	≥95%
HY-P71972	IL-36 gamma/IL-1F9 Protein, Human	Q9NZH8 (S18-D169)	≥95%
HY-P75861	IL-36 gamma/IL-1F9 Protein, Human (152a.a, His)	Q9NZH8-1 (S18-D169)	≥95%
HY-P75861AF	Animal-Free IL-36 gamma/IL-1F9 Protein, Human (His)	Q9NZH8-1 (S18-D169)	≥95%

关联疾病

疾病名称

别名

Acute Generalized Exanthematous Pustulosis

Agep	Pustular Drug Eruption
Toxic Pustuloderma

Psoriasis

Psoriasis 6

PSORS6	Psoriasis Susceptibility 6
Psoriasis 6, Susceptibility To

Psoriasis 5

PSORS5	Psoriasis Susceptibility 5
Psoriasis 5, Susceptibility To

Impetigo Herpetiformis

Psoriasis 14, Pustular

Generalized Pustular Psoriasis	Gpp
Ditra	Acrodermatitis Continua Of Hallopeau
Palmoplantar Pustulosis	PSORS14
Interleukin 36 Receptor Antagonist Deficiency	Psorp
Pustular Psoriasis 14	Deficiency Of Il-36r Antagonist
Acute Generalised Pustular Psoriasis	Deficiency Of The Interleukin-36 Receptor Antagonist
Generalized Pustular Psoriasis Of Von Zumbusch	Von Zumbusch Psoriasis
Deficiency Of Il-36ra	Psoriasis, Pustular, Generalized
Psoriasis, Pustular, Type 14	Pustulosis Of Palms And Soles
Acute Generalized Pustular Psoriasis	Palmoplantar Pustular Psoriasis
Pustulosis Palmaris Et Plantaris	Ppp - [Palmoplantar Pustulosis]
Pustular Psoriasis Of The Palms And Soles	Pustular Bacterid

Autoimmune Lymphoproliferative Syndrome, Type Iii

ALPS3	Autoimmune Lymphoproliferative Syndrome Type 3
Immunodeficiency, Common Variable, 9, Formerly	Cvid9, Formerly
Autoimmune Lymphoproliferative Syndrome Type Iii	Autoimmune Lymphoproliferative Syndrome 3
Cvid9	Immunodeficiency, Common Variable, 9
Type 3 Autoimmune Lymphoproliferative Syndrome	Immunodeficiency, Variable, Common, Type 9

Pityriasis Rubra Pilaris

PRP	Devergie'S Disease
Prp - [Pityriasis Rubra Pilaris]

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS06761	IL36G Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	IL36G	MGD	MGI:2449929
Macaca mulatta	IL36G	VGNC	VGNC:73605
Bos taurus	IL36G	VGNC	VGNC:30158
Rattus norvegicus	IL36G	RGD	RGD:1563019
Others	IL36G	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。沪(浦)应急管危经许[2021]201709(QFYS)

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IL36G - interleukin 36 gamma Gene

关于 IL36G

功能概要

IL36G 基因产物(2)

IL36G 蛋白结构

重组 IL36G 蛋白

关联疾病

直系同源

热门区域

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IL36G - interleukin 36 gamma Gene

关于 IL36G

功能概要

IL36G 基因产物(2)

IL36G 蛋白结构

重组 IL36G 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z