2. Anti-infection
  3. RSV
  4. Gontivimab

Gontivimab  (Synonyms: ALX-0171; VR-465)

目录号: HY-P99647

摩尔计算器

Gontivimab (ALX-0171; VR-465) 是一种有效的抗RSV 预融合 F 蛋白 纳米抗体，KD 值为 0.113 nM。Gontivimab 显示出抗病毒活性。Gontivimab 可降低鼻腔和肺部的 RSV 负荷。

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Gontivimab Chemical Structure

Gontivimab Chemical Structure

CAS No. : 1257358-38-5

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Gontivimab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Gontivimab (ALX-0171; VR-465) is a poent anti-RSV prefusion F protein nanobody with a KD value of 0.113 nM. Gontivimab shows antiviral activity. Gontivimab reduces the RSV load in the nose and lung[1].

IC50 & Target

KD: 0.113 nM (RSV prefusion F protein)[1]
体外研究
(In Vitro)

Gontivimab (0-100000 nM) 显示出抗病毒活性，对 RSV-A、RSV-B 18537 菌株的 IC50 分别为 0.1、0.4 nM[1]。
Gontivimab 与 F 蛋白的抗原位点 II 结合[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Gontivimab 相关抗体:
体内研究
(In Vivo)

Gontivimab (1-68 mg/kg；鼻内给药或雾化) 降低大鼠鼻腔和肺部的 RSV 负荷[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats (RSV Tracy)[1]
Dosage: 1-68 mg/kg
Administration: Intranasal administration or nebulization; once (day 2 or day 3) or twice (day 2 and day 3)
Result: Resulted in significant viral load reductions in the lungs ranging.
CAS 号
中文名称

格替韦单抗
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Gontivimab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gontivimab1257358-38-5ALX-0171 VR-465格替韦单抗ALX0171ALX 0171VR465VR 465VR-465RSVRespiratory syncytial virusantiviralRSV-ARSV-B 18537intranasal administrationnebulizationviral loadInhibitorinhibitorinhibit

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