2. Epigenetics Protein Tyrosine Kinase/RTK JAK/STAT Signaling Stem Cell/Wnt
  3. JAK Syk
  4. Gusacitinib hydrochloride

Gusacitinib hydrochloride  (Synonyms: ASN-002 hydrochloride)

目录号: HY-103018A
产品使用指南

摩尔计算器

Gusacitinib (ASN-002) hydrochloride 是一种口服有效的 SYK/JAK 激酶双重抑制剂，其抑制 SYK、JAK1、JAK2、JAK3 和 TYK2 的 IC50 值分别为 5, 46, 4, 11 和 8 nM。Gusacitinib hydrochloride 能快速且显著抑制与特应性皮炎发病机制有关的关键炎症通路。Gusacitinib hydrochloride 可用于慢性手部湿疹和癌症 (如基底细胞癌) 的研究。

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Gusacitinib hydrochloride Chemical Structure

Gusacitinib hydrochloride Chemical Structure

CAS No. : 2228989-14-6

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Gusacitinib hydrochloride 的其他形式现货产品:

Customer Review

Other Forms of Gusacitinib hydrochloride:

Gusacitinib hydrochloride 相关抗体

Top Publications Citing Use of Products

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Gusacitinib (ASN-002) hydrochloride is an orally active dual SYK/JAK kinase inhibitor with IC50 values of 5, 46, 4, 11 and 8 nM for SYK, JAK1, JAK2, JAK3 and TYK2, respectively. Gusacitinib hydrochloride rapidly and significantly suppressed key inflammatory pathways implicated in atopic dermatitis pathogenesis. Gusacitinib hydrochloride can be used in the research of chronic hand eczema and cancers such as basal cell carcinoma[1][2].

IC50 & Target

IC50: 5-46 nM (SYK, JAK)[2].
体外研究
(In Vitro)

Gusacitinib hydrochloride 在包括 DHL6、DHL4、OCI-LY10、H929、Pfeiffer、HT-1376 和 Lovo 在内的广泛的人类癌症细胞系中显示出抗增殖活性，表明其对实体瘤和血液病类型都有活性[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Gusacitinib hydrochloride 相关抗体:
体内研究
(In Vivo)

Gusacitinib hydrochloride 在多发性骨髓瘤 (H929) 异种移植模型中抑制肿瘤生长 (>95%)[3]。
Gusacitinib hydrochloride 显著推迟人类红血病 (HEL) 小鼠模型中后肢瘫痪的发生[3]。
Gusacitinib hydrochloride 在大鼠和狗的毒理学研究中表现出良好的安全性[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

496.99

Formula

C24H29ClN8O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Gusacitinib hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gusacitinib2228989-14-6ASN-002ASN002ASN 002JAKSykJanus kinaseSpleen tyrosine kinasecancereczemainflammatoryInhibitorinhibitorinhibit

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