Heliquinomycin 

Heliquinomycin is an inhibitor of DNA helicase (K_i: 6.8 μM) and inhibits DNA and RNA synthesis. Heliquinomycin is effective against Gram-positive bacteria strains. Heliquinomycin inhibits cancer cell growth^[1][2].

Heliquinomycin (18 h) 对革兰氏阳性菌株表现出很强的抑制活性，MIC 值为 0.1-0.39 μM^[1]。
Heliquinomycin 抑制 HeLa S3、LI210 白血病、IMC、癌、B16 黑色素瘤细胞的生长，IC₅₀s 为 0-1.6 μg/mL^[1]。
Heliquinomycin (30 和 100 μg/mL) 抑制拓扑异构酶 II 和 I 酶活性^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Heliquinomycin (100 mg/kg, i.p.) 对小鼠没有任何毒性^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

698.58

C₃₃H₃₀O₁₇

178182-49-5

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Chino M, et al. Heliquinomycin, a new inhibitor of DNA helicase, produced by Streptomyces sp. MJ929-SF2 I. Taxonomy, production, isolation, physico-chemical properties and biological activities. J Antibiot (Tokyo). 1996 Aug;49(8):752-7.  [Content Brief]

  [2]. Chino M,et al. Effect of a novel antibiotic, heliquinomycin, on DNA helicase and cell growth. J Antibiot (Tokyo). 1998 May;51(5):480-6.  [Content Brief]