2. JAK/STAT Signaling Stem Cell/Wnt Apoptosis
  3. STAT Apoptosis
  4. HJC0416

HJC0416 是一种有效的口服活性 STAT3 抑制剂 HJC0416 显示出抗增殖活性并诱导细胞凋亡 (apoptosis). HJC0416 降低 p-STAT3 (Tyr-705)、Cyclin D1 的表达并增加cleaved caspase-3 蛋白的表达。HJC0416 显示出抗肿瘤活性。

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HJC0416 Chemical Structure

HJC0416 Chemical Structure

CAS No. : 1617518-22-5

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HJC0416 相关抗体

Top Publications Citing Use of Products

查看 STAT 亚型特异性产品:

查看所有亚型
STAT3 STAT5 STAT6 STAT1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HJC0416 is a potent and orally active STAT3 inhibitor. HJC0416 shows antiprolifeative activity and induces apoptosis. HJC0416 decreases the expression of p-STAT3 (Tyr-705), Cyclin D1 and increases the expression of cleaved caspase-3 protein. HJC0416 shows anti-tumor activity[1].

IC50 & Target[1]

STAT3

 

体外研究
(In Vitro)

HJC0416 (0-10 µM; 48 h) 在 MDA-MB-231 细胞中显示抗增殖活性并诱导细胞凋亡[1]。
HJC0416 (0-10 µM; 12 h) 降低 p-STAT3 (Tyr-705)、Cyclin D1 的表达并增加cleaved caspase-3 蛋白的表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HJC0416 相关抗体:

Cell Proliferation Assay[1]

Cell Line: MCF-7, MDA-MB-231, AsPC1, Panc-1 cells
Concentration: 0-100 µM
Incubation Time: 72 h
Result: Showed antiproliferative activity with IC50s 1.76, 1.97, 0.04, 1.88 µM for MCF-7, MDA-MB-231, AsPC1, Panc-1 cells, respectively.

Apoptosis Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 1, 5, 10 µM
Incubation Time: 48 h
Result: Induced cell apoptosis.

Western Blot Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 0, 1, 5, 10 µM
Incubation Time: 12 h
Result: Suppressed the expression of phosphorylated STAT3 at Tyr-705, Cyclin D1, increased the expression of cleaved caspase-3.
体内研究
(In Vivo)

HJC0416 (腹腔注射 10 mg/kg；口服 100 mg/kg；每日一次，持续 7 天) 在小鼠中减少肿瘤生长，体重没有明显减轻[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6 weeks, female nude mice (MDA-MB-231 cells)[1]
Dosage: 10 mg/kg for i.p.; 100 mg/kg for p.o.
Administration: I.p. or p.o.; daily for 7 days
Result: Decreased the tumor volume for 67% as compared to the control mice for i.p.; the growth of xenograft tumors in mice was also significantly reduced at a dose of 100 mg/kg by 46%.
分子量

392.86

Formula

C18H17ClN2O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HJC0416 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HJC04161617518-22-5HJC 0416HJC-0416STATApoptosisantiprolifeativeantitumororally activeapoptosisMDA-MB-231 cellsp-STAT3 (Tyr-705)Cyclin D1cleaved caspase-3Inhibitorinhibitorinhibit

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