1. Signaling Pathways
  2. Apoptosis
  3. Apoptosis

Apoptosis

Apoptosis is a distinctive form of cell death exhibiting specific morphological and biochemical characteristics, including cell membrane blebbing, chromatin condensation, genomic DNA fragmentation, and exposure of specific phagocytosis signaling molecules on the cell surface. Cells undergoing apoptosis differ from those dying through necrosis. Necrotic cells are usually recognized by the immune system as a danger signal and, thus, resulting in inflammation; in contrast, apoptotic death is quiet and orderly.

There are two major pathways of apoptotic cell death induction: The intrinsic pathway, also called the Bcl-2-regulated or mitochondrial pathway, is activated by various developmental cues or cytotoxic insults, such as viral infection, DNA damage and growth-factor deprivation, and is strictly controlled by the BCL-2 family of proteins. The extrinsic or death-receptor pathway is triggered by ligation of death receptors (members of the tumor necrosis factor (TNF) receptor family, such as Fas or TNF receptor-1 (TNFR1)) that contain an intracellular death domain, which can recruit and activate caspase-8 through the adaptor protein Fas-associated death domain (FADD; also known as MORT1) at the cell surface. This recruitment causes subsequent activation of downstream (effector) caspases, such as caspase-3, -6 or -7, without any involvement of the BCL-2 family.

Studies suggest that alterations in cell survival contribute to the pathogenesis of a number of human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency syndrome). Treatments designed to specifically alter the apoptotic threshold may have the potential to change the natural progression of some of these diseases.

Apoptosis 相关产品 (345):

Cat. No. Product Name Effect Purity
  • HY-10227
    Bortezomib Activator 99.97%
    Bortezomib (PS-341) 是一种细胞渗透性、可逆性和选择性的蛋白酶体抑制剂,通过靶向苏氨酸残基有效抑制 20S 蛋白酶体 (Ki=0.6 nM)。Bortezomib (PS-341) 破坏细胞周期、诱导细胞凋亡以及抑制核因子 NF-κB。Bortezomib (PS-341) 是一种抗癌药物,也是第一种用于人类的蛋白酶体抑制剂。
  • HY-13453
    BAY 11-7082 Activator 99.42%
    BAY 11-7082 (BAY 11-7821) 是 IKK 抑制剂, 其通过抑制 TNF-α 诱导的 IκB-α 磷酸化来降低 NF-κB。 BAY 11-7082 抑制泛素化蛋白酶 USP7USP21IC50 分别为 0.19 μM 和 0.96 μM。11-7082 有效抑制人体和小鼠细胞中脂质体中的 GSDMD 孔形成,炎性体介导的细胞凋亡和 IL-1β 分泌。
  • HY-13629
    Etoposide Activator 99.65%
    Etoposide (VP-16; VP-16-213) 是用于治疗多种癌症的化疗药物,通过与拓扑异构酶 II 和 DNA 形成复合物来抑制DNA合成。Etoposide 阻断细胞周期 G2 期并诱导细胞凋亡。
  • HY-B1756
    Rotenone Activator 98.12%
    Rotenone 是线粒体电子传递链复合物I抑制剂。 Rotenone 通过促进线粒体活性氧的产生来诱导细胞凋亡。
  • HY-13520
    Nocodazole Activator 98.68%
    Nocodazole是快速可逆的 microtubule 抑制剂。 Nocodazole与β-微管蛋白结合并破坏微管组装/拆卸动力学,从而防止有丝分裂并诱导肿瘤细胞凋亡。Nocodazole 抑制 Bcr-Abl,增强 CRISPR/Cas9 的活性。
  • HY-19696B
    Tauroursodeoxycholate dihydrate Inhibitor
    Tauroursodeoxycholate dihydrate (TUDCA dihydrate; UR 906 dihydrate; Taurolite dihydrate) 是一种内质网应激抑制剂。Tauroursodeoxycholate 显著降低凋亡分子如 caspase-3caspase-12 表达。Tauroursodeoxycholate 也抑制 ERK
  • HY-117282
    JG-98 Activator 99.97%
    JG-98 是一种热休克蛋白 70 (Hsp70) 变构抑制剂,可与 Hsp70 上的保守位点紧密结合,打断 Hsp70-Bag3 相互作用。JG-98 影响癌细胞和肿瘤相关巨噬细胞,显示抗癌活性。
  • HY-N0375
    18α-Glycyrrhetinic acid Activator 99.19%
    18α-Glycyrrhetinic acid,一种饮食衍生的化合物,是 NF-kB 的抑制剂和蛋白酶体 (proteasome) 的激活剂,在多细胞生物中起到促进长寿和抗聚集因子的作用。18α-Glycyrrhetinic acid 诱导细胞凋亡。
  • HY-10971
    Alisertib Activator 99.84%
    Aliertib (MLN 8237) 是一种口服活性和选择性的 Aurora A 激酶抑制剂 (IC50=1.2 nM),与Aurora A 激酶结合,导致有丝分裂纺锤体异常、有丝分裂累积。Aliertib (MLN 8237) 通过靶向白血病细胞中的 AKT/mTOR/AMPK/p38 途径诱导其凋亡和自噬。具有抗肿瘤活性。
  • HY-18950
    GSK2795039 Inhibitor 99.44%
    GSK2795039 是一种 NADPH 氧化酶 2 (NOX2) 抑制剂,在不同的无细胞试验中平均 pIC50 为 6,抑制活性氧 (Reactive Oxygen Species) 产生和 NADPH 消耗。GSK2795039 可减少细胞凋亡 (apoptosis)。
  • HY-13251
    Silvestrol Activator 98.00%
    Silvestrol 是从 Aglaia foveolata 的果实和枝条中分离的真核翻译起始因子 (eIF4A) 抑制剂。Silvestrol 诱导细胞自噬以及 caspase 介导的细胞凋亡。
  • HY-15149
    Romidepsin Activator 99.98%
    Romidepsin (FK 228) 是具有抗肿瘤活性的组蛋白去乙酰化酶 (HDAC) 抑制剂,抑制 HDAC1,HDAC2,HDAC4 和 HDAC6,IC50 值分别为 36 nM,47 nM,510 nM 和 1.4 μM。Romidepsin (FK 228) 由紫色杆菌产生,诱导 G2/M 细胞周期阻滞和凋亡 (apoptosis)。
  • HY-16046
    Rimiducid Activator 99.81%
    Rimiducid (AP1903) 是二聚化剂,其通过交联 FKBP 结构域起作用,启动 Fas 信号传导,引起凋亡。Rimiducid (AP1903) 使 Caspase 9 自杀开关二聚化,并迅速诱导细胞凋亡 (apoptosis)。
  • HY-16591
    Birinapant Activator 99.36%
    Birinapant (TL32711) 是一种二价 Smac 模拟物,是 XIAPcIAP1 的强效拮抗剂,Kd 值分别为 45 nM 和小于 1 nM。Birinapant (TL32711) 诱导完整细胞中 cIAP1 和 cIAP2 的自身泛素化和蛋白酶体降解,从而形成 RIPK1: caspase-8 复合物,caspase-8 活化和诱导肿瘤细胞死亡。Birinapant (TL32711) 靶向与 TRAF2 相关的 cIAP,并消除 TNF 诱导的 NF-κB 活化。
  • HY-10029
    Nutlin (3a) Activator 98.11%
    Nutlin 3a 是 Nutlin-3 的活性异构体,为一种鼠双微体 2 (MDM2) 抑制剂,抑制 MDM2-p53 相互作用,且稳定 p53 蛋白,因此诱导细胞周期停滞和细胞凋亡。
  • HY-B0240
    Disulfiram Inhibitor 98.67%
    Disulfiram (Tetraethylthiuram disulfide) 是特异性的乙醛脱氢酶1型抗体 (ALDH1) 抑制剂,可以通过对酒精产生急性敏感性来治疗慢性酗酒。Disulfiram 有效抑制人体和小鼠细胞中脂质体中的 GSDMD 孔形成,炎性体介导的细胞凋亡和 IL-1β 分泌。
  • HY-19696A
    Tauroursodeoxycholate Sodium Inhibitor
    Tauroursodeoxycholate Sodium 是一种内质网应激抑制剂。Tauroursodeoxycholate 显著降低凋亡分子如 caspase-3caspase-12 表达。Tauroursodeoxycholate 也抑制 ERK
  • HY-14596
    Genistein Activator 99.68%
    Genistein是一种大豆异黄酮,是一种多重的酪氨酸激酶 (tyrosine kinases,比如 EGFR) 抑制剂,是对多种癌症的化疗剂,主要通过改变细胞凋亡 (apoptosis),细胞周期和血管生成以及抑制转移。
  • HY-13433
    Thapsigargin Activator 99.00%
    Thapsigargin 是一种微粒体 Ca2+-ATPase 抑制剂。Thapsigargin 是一种表征良好的内质网应激诱导剂。
  • HY-16291
    APTO-253 Activator
    APTO-253 是一种小分子,可抑制c-Myc表达,稳定 G-四链体 DNA 并诱导急性髓样白血病细胞的细胞周期停滞和凋亡。APTO-253 通过诱导 Kruppel-like factor 4 (KLF4) 抑癌因子介导抗癌活性。
Isoform Specific Products

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.