Imazalil sulfate  (Synonyms: 抑霉唑硫酸盐; Enilconazolel sulfate)

Imazalil (Enilconazole) sulfate is a fungicide. Imazalil sulfate has oral activity and strongly activates mPXR but not mCAR in mouse liver. Imazalil sulfate is commonly used to protect various agricultural crops against fungal attack. Imazalil sulfate induces developmental abnormalities, gut microbiota dysbiosis, and hepatic metabolism disorder^[1][2][3].

Imazalil (Enilconazole；3、10、30 μM；持续 6 小时) sulfate 显着抑制 IL-17 mRNA^[1]。
Imazalil (1、3、10、30、100 μM；持续 24 小时) sulfate 仅在 mPXR 表达的 HepG2 细胞中剂量依赖性地诱导报告基因表达^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Imazalil (Enilconazole；25-100 mg/kg；腹腔给药) sulfate 以剂量依赖性方式显着增加肝脏 Cyp3a11 mRNA 水平^[2]。
Imazalil (75 mg/kg；腹腔注射；两次；每天一次) sulfate 与 TCPOBOP (3 mg/kg) 联合使用，与单一治疗相比，大大增加了 Ki-67 阳性细胞核的数量和 Mcm2 mRNA 水平。Imazalil sulfate 可加速 TCPOBOP 治疗介导的小鼠肝细胞增殖^[2]。
Imazalil (0.1、0.5、2.5 mg/kg；饮用水中；持续 15 周) sulfate 在雄性成年 C57BL/6 小鼠中诱导氧化应激并导致胆汁酸代谢紊乱^[3]。

395.26

C₁₄H₁₆Cl₂N₂O₅S

58594-72-2

抑霉唑硫酸盐； 伊米萨利硫酸盐； 烯菌灵硫酸盐

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Hiroyuki Kojima, et al. Inhibitory effects of azole-type fungicides on interleukin-17 gene expression via retinoic acid receptor-related orphan receptors α and γ. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):338-45.  [Content Brief]

  [2]. Shohei Yoshimaru, et al. Acceleration of murine hepatocyte proliferation by imazalil through the activation of nuclear receptor PXR. J Toxicol Sci. 2018;43(7):443-450.  [Content Brief]

  [3]. Cuiyuan Jin, et al. Chronic exposure of mice to low doses of imazalil induces hepatotoxicity at the physiological, biochemical, and transcriptomic levels. Environ Toxicol. 2018 Jun;33(6):650-658.  [Content Brief]