2. MAPK/ERK Pathway Metabolic Enzyme/Protease
  3. JNK Cytochrome P450
  4. JNK-IN-14

JNK-IN-14 是一种有效的 JNK 抑制剂，对 JNK1、JNK2 和 JNK3 的 IC50 值分别为 1.81, 12.7 和 10.5 nM。 JNK-IN-14 诱导早期细胞凋亡 (apoptosis)。JNK-IN-14 在 G2/M 期导致细胞群阻滞，相对于 SP600125 (HY-12041，在 K562 白血病细胞处略微抑制了 Beclin-1 的产生，表现出更强的抑制能力。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

JNK-IN-14 Chemical Structure

JNK-IN-14 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

JNK-IN-14 相关抗体

Top Publications Citing Use of Products

查看 JNK 亚型特异性产品:

查看所有亚型
JNK1 JNK2 JNK3 JNK

查看 Cytochrome P450 亚型特异性产品:

查看所有亚型
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

JNK-IN-14 is a potent JNK inhibitor with IC50 values of 1.81, 12.7 and 10.5 nM for JNK1, JNK2 and JNK3, respectively. JNK-IN-14 induces early-stage apoptosis. JNK-IN-14 shows cell population arrest at the G2/M phase and slightly inhibits beclin-1 production at K562 leukemia cells relative to SP600125 (HY-12041), showing higher inhibitory ability.[1]

IC50 & Target

JNK1

1.82 nM (IC50)

JNK2

10.5 nM (IC50)

JNK3

10.5 nM (IC50)

CYP2D6

26.7 ± 0.5 nM (IC50)

CYP3A4

383.0 ± 1. nM (IC50)

体外研究
(In Vitro)

JNK-IN-14 (compound 11e) (2.5-5 μM, 24 h) 在 K562 细胞中以浓度依赖性的方式引起轻微的早期细胞凋亡 (apoptosis)[1]。< br / > JNK-IN-14 (1.25-5 μM, 24 h) 与 SP600125 相比，在更高浓度下可以抑制 K562 细胞群，具有更高的抑制能力[1]。< br / >

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

JNK-IN-14 相关抗体:

Apoptosis Analysis

Cell Line: K562 Human Leukemia Cell
Concentration: 2.5 μM, 5 μM
Incubation Time: 24 h
Result: Resulted in early-stage apoptosis with 1.94%, and 2.14% for 2.5 and 5 μM, respectively.

Cell Cycle Analysis[1]

Cell Line: K562 human leukemia cell
Concentration: 1.25 μM, 2.56 μM, 5 μM
Incubation Time: 24 h
Result: Showed viable cells arrest at the G2/M phase with values of 45.33% at 1.25 μM, 2.5 μM at 62.99%, and 5 μM at 98.97%.
分子量

521.63

Formula

C27H31N5O4S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

JNK-IN-14 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNK-IN-14JNKCytochrome P450c-Jun N-terminal kinaseCYPsInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
JNK-IN-14
目录号：
HY-156182
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z