2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. KRAS G12D inhibitor 16

KRAS G12D inhibitor 16 是一种 KRAS G12D 抑制剂。KRAS G12D inhibitor 16 对 KRAS G12D 和 KRAS G12D 突变具有抑制活性，IC50 值分别为 0.7 nM 和 0.35 μM。KRAS G12D inhibitor 16 可用于多种恶性肿瘤的研究，如胰腺导管腺癌（PDAC）、结肠直肠癌（CRC）、非小细胞肺癌（NSCLC）。

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KRAS G12D inhibitor 16 Chemical Structure

KRAS G12D inhibitor 16 Chemical Structure

CAS No. : 2648221-12-7

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KRAS G12D inhibitor 16 相关抗体

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  • 生物活性

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生物活性

KRAS G12D inhibitor 16 is a KRAS G12D inhibitor. KRAS G12D inhibitor 16 has inhibitory activity against KRAS G12D and KRAS G12D mutation with IC50 value of 0.7 nM and 0.35 μM, respectively. KRAS G12D inhibitor 16 can be used for the research of many malignant tumor, such as pancreatic ductal adenocarcinomas (PDAC), colon and rectal carcinomas (CRC), non-small cell lung carcinomas (NSCLC)[1].

IC50 & Target

KRas G12D

0.7 nM (IC50)

体外研究
(In Vitro)

KRAS G12D inhibitor 16 has inhibitory activity for G12 with an IC50 value of 0.7 nM[1].
KRAS G12D inhibitor 16 shows growth inhibition activity KRAS-G12D mutant cell line (A-427) with an IC50 value of 0.35 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

KRAS G12D inhibitor 16 相关抗体:
分子量

682.59

Formula

C32H39IN6O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

KRAS G12D inhibitor 16 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KRAS G12D inhibitor 162648221-12-7RasantitumorKRAS G12Dinhibitorypancreatic ductal adenocarcinomas (PDAC)colon and rectal carcinomas (CRC)non-small cell lung carcinomas (NSCLC)Inhibitorinhibitorinhibit

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