2. Inhibitory Antibodies
  3. KY-1044

KY-1044  (Synonyms: 艾洛利单抗; Alomfilimab; SAR 445256)

目录号: HY-P99431 纯度: 99.51%
COA

摩尔计算器

KY-1044 (Alomfilimab; SAR 445256) 是一种针对诱导型共刺激受体 (ICOS) 的全人 IgG1 抗体。KY-1044 在 FcgRIIIa 参与下，通过抗体依赖性细胞毒性 (ADCC) 消耗 ICOS 高的细胞。KY-1044 在表达较低 ICOS 水平的细胞上充当共刺激分子，例如 CD8+ TEff 细胞(通过 FcgR 依赖性聚集)。KY-1044 利用 ICOS 在 T 细胞亚型上的差异表达来改善肿瘤内免疫环境并恢复抗肿瘤免疫反应。

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KY-1044 Chemical Structure

KY-1044 Chemical Structure

CAS No. : 2489390-15-8

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5 mg ￥7500
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KY-1044 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

KY-1044 (Alomfilimab; SAR 445256) is a fully human IgG1 antibody targeting inducible costimulatory receptor (ICOS). KY-1044 depletes ICOShigh cells via antibody-dependent cellular cytotoxicity (ADCC) through the engagement of FcgRIIIa. KY-1044 act as a costimulatory molecule on cells expressing lower ICOS levels, such as CD8+ TEff cells (through FcgR-dependent clustering). KY-1044 exploit the differential expression of ICOS on T-cell subtypes to improve the intratumoral immune contexture and restore an antitumor immune response[1].

同型

Human IgG1 kappa
推荐同型对照抗体
种属

Human
体外研究
(In Vitro)

KY-1044 (Alomfilimab; SAR 445256; 0-100ng/mL; 4 小时)导致表达 hICOS (5:1 效应子: 靶细胞比例) 的人类自然杀伤 (NK) 细胞诱导有效的 ADCC 介导的杀伤 (EC50=5.6 pmol/L)[1]。
KY-1044 显着诱导荧光素酶信号 (EC50 为 0.15 nmol/L)，对小鼠 ICOS (0.53 nmol/L)、大鼠 ICOS (0.48 nmol/L) 或食蟹猴 ICOS (0.22 nmol/L) 获得了相似的 EC50[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

KY-1044 相关抗体:
体内研究
(In Vivo)

KY-1044 (Alomfilimab; SAR 445256; 10 mg/kg; 腹腔注射; 每周两次; 持续 3 周) mIgG2a (效应物启用) 单一疗法可阻断淋巴瘤/骨髓瘤肿瘤模型中的肿瘤生长[1]。
在同基因小鼠肿瘤模型中，KY-1044 耗尽 ICOShigh Treg 并增加瘤内 TEff:Treg 比率，导致 T 分泌 IFNγ 和 TNFα 增加 Eff 细胞[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 8- to 10-week-old wild-type female Balb/C or C57BL/6J mice with A20 cells[1]
Dosage: 200 μg (10 mg/kg)
Administration: IP; twice a week for 3 weeks starting from 6 days following tumor cell implantation
Result: Triggered an antitumor response, with more than 90% of the mice being free from measurable disease at the end of the study (day 42).
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

艾洛利单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KY-10442489390-15-8Alomfilimab SAR 445256艾洛利单抗KY1044KY 1044SAR445256SAR 445256SAR-445256OthersHumanIgG1antibodyinducible costimulatory receptorICOSantibody-dependent cellular cytotoxicityADCCFcgRIIIaCD8+ TEff cellsFcgRimmune responseInhibitorinhibitorinhibit

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