2. Metabolic Enzyme/Protease GPCR/G Protein
  3. Endogenous Metabolite Leukotriene Receptor
  4. Leukotriene B4 ethanolamide

Leukotriene B4 ethanolamide  (Synonyms: LTB4 ethanolamide)

目录号: HY-131651
产品使用指南

摩尔计算器

Leukotriene B4 ethanolamide (LTB4 ethanolamide) 是白三烯B4 受体 1 (BLTR1) 的拮抗剂和部分激动剂。Leukotriene B4 ethanolamide 可改善仅与炎症有关的肿瘤进展。

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Leukotriene B4 ethanolamide Chemical Structure

Leukotriene B4 ethanolamide Chemical Structure

CAS No. : 877459-63-7

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Leukotriene B4 ethanolamide 相关抗体

Top Publications Citing Use of Products

查看 Leukotriene Receptor 亚型特异性产品:

查看所有亚型
LTB4 LTC4/CysLT2 LTD4/CysLT1 LTE4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Leukotriene B4 ethanolamide (LTB4 ethanolamide) is an antagonist and a partial agonist for Leukotriene B4 (LTB4) receptor 1 (BLTR1). Leukotriene B4 ethanolamide ameliorates the tumor progression, which is only asscociated with inflammation[1][2].

IC50 & Target

Human Endogenous Metabolite

 

体外研究
(In Vitro)

Leukotriene B4 ethanolamide 可抑制豚鼠离体肺实质中 LTB 4 的收缩作用，Kb 为 7.28 nM[1]。
Leukotriene B4 ethanolamide (1 μM) 作为 PMN 细胞中 BLT 受体的部分激动剂，诱导 PMN 迁移，pEC50 为 7[2]。
Leukotriene B4 ethanolamide (1 μM) 刺激 TRPV1 表达的大鼠 CHO 细胞中 Ca2+ 释放，pEC50 为 7.28[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Leukotriene B4 ethanolamide 相关抗体:

Cell Migration Assay [2]

Cell Line: PMN
Concentration: 1 μM
Incubation Time:
Result: Induced migration of neutrophils.
体内研究
(In Vivo)

Leukotriene B4 ethanolamide (100 nM/mouse/day，皮下注射，共 5 天) 可抑制 C57BL/6 小鼠模型中与炎症相关的肿瘤进展[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Melanoma tumor in C57BL/6 mouse models[2]
Dosage: 100 nM/mouse
Administration: s.c., once a day for 5 days
Result: Inhibited melanoma tumor growth in mice coinjected with apoptotic Tm1 melanoma cells and a subtumorigenic dose of Tm1.
分子量

379.53

Formula

C22H37NO4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Leukotriene B4 ethanolamide 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Leukotriene B4 ethanolamide877459-63-7LTB4 ethanolamideEndogenous MetaboliteLeukotriene ReceptorPMNC57BL/6 micemelanoma tumorInhibitorinhibitorinhibit

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