2. Academic Validation
  3. Phenylpropenamide derivatives as inhibitors of hepatitis B virus replication

Phenylpropenamide derivatives as inhibitors of hepatitis B virus replication

  • Bioorg Med Chem Lett. 2000 Dec 4;10(23):2687-90. doi: 10.1016/s0960-894x(00)00544-8.
R B Perni 1,  S C Conway,  S K Ladner,  K Zaifert,  M J Otto,  R W King
Affiliations

Affiliation

  • 1 Avid Therapeutics, Inc., Philadelphia, PA 19104, USA. robert_perni@vpharm.com
PMID: 11128652 DOI: 10.1016/s0960-894x(00)00544-8
Abstract

A non-nucleoside class of compounds that inhibits the replication of hepatitis B virus (HBV) in Cell Culture has been discovered. A series of substituted analogues of phenylpropenamide 6 has been prepared and evaluated in the HepAD38 cellular assay. Structure-activity relationships of this series are discussed.

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