2. Academic Validation
  3. Phenylpropenamide derivatives AT-61 and AT-130 inhibit replication of wild-type and lamivudine-resistant strains of hepatitis B virus in vitro

Phenylpropenamide derivatives AT-61 and AT-130 inhibit replication of wild-type and lamivudine-resistant strains of hepatitis B virus in vitro

  • Antimicrob Agents Chemother. 2002 Sep;46(9):3057-60. doi: 10.1128/AAC.46.9.3057-3060.2002.
William E Delaney 4th 1,  Ros Edwards,  Danni Colledge,  Tim Shaw,  Phil Furman,  George Painter,  Stephen Locarnini
Affiliations

Affiliation

  • 1 Victorian Infectious Diseases Reference Laboratory, North Melbourne, Victoria 3051, Australia.
PMID: 12183271 DOI: 10.1128/AAC.46.9.3057-3060.2002
Abstract

The phenylpropenamide derivatives AT-61 and AT-130 are nonnucleoside analogue inhibitors of hepatitis B virus (HBV) replication. They inhibited the replication of wild-type HBV with 50% inhibitory concentrations of 21.2 +/- 9.5 and 2.40 +/- 0.92 micro M, respectively, compared to 0.064 +/- 0.020 micro M lamivudine. There were no significant differences in sensitivity between wild-type and nucleoside analogue-resistant (rtL180M, rtM204I, and rtL180M + rtM204V) HBV.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z