2. Academic Validation
  3. Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels

Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels

  • Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41. doi: 10.1016/j.bmcl.2005.11.108.
Kathleen H Mortell 1,  David J Anderson,  James J Lynch 3rd,  Sherry L Nelson,  Kathy Sarris,  Heath McDonald,  Reza Sabet,  Scott Baker,  Prisca Honore,  Chih-Hung Lee,  Michael F Jarvis,  Murali Gopalakrishnan
Affiliations

Affiliation

  • 1 Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA. kathleen.mortell@abbott.com
PMID: 16380257 DOI: 10.1016/j.bmcl.2005.11.108
Abstract

A series of alpha-amino acids were identified as ligands which compete with gabapentin for binding to the alpha(2)delta subunit of voltage-dependent Ca(2+) channels. Potent analogs were identified. Their activity in an in vivo pain assay is described.

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