1. Academic Validation
  2. A769662, a novel activator of AMP-activated protein kinase, inhibits non-proteolytic components of the 26S proteasome by an AMPK-independent mechanism

A769662, a novel activator of AMP-activated protein kinase, inhibits non-proteolytic components of the 26S proteasome by an AMPK-independent mechanism

  • FEBS Lett. 2008 Jul 23;582(17):2650-4. doi: 10.1016/j.febslet.2008.06.044.
Daniel Moreno 1 Erwin Knecht Benoit Viollet Pascual Sanz
Affiliations

Affiliation

  • 1 Instituto de Biomedicina de Valencia, CSIC, Jaime Roig 11, Valencia, Spain.
Abstract

In this work we present evidence that A769662, a novel activator of AMP-activated protein kinase (AMPK), is able to inhibit the function of the 26S Proteasome by an AMPK-independent mechanism. Contrary to the mechanism of action of most Proteasome inhibitors, A769662 does not affect the proteolytic activities of the 20S core subunit, defining in this way a novel mechanism of inhibition of 26S Proteasome activity. Inhibition of Proteasome activity by A769662 is reversible and leads to an arrest of cell cycle progression. These side effects of this new activator of AMPK should be taken into account when this compound is used as an alternative activator of the kinase.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-50662
    99.20%, AMPK激动剂