2. Academic Validation
  3. Role of lipid peroxidation derived 4-hydroxynonenal (4-HNE) in cancer: focusing on mitochondria

Role of lipid peroxidation derived 4-hydroxynonenal (4-HNE) in cancer: focusing on mitochondria

  • Redox Biol. 2015;4:193-9. doi: 10.1016/j.redox.2014.12.011.
Huiqin Zhong 1,  Huiyong Yin 2
Affiliations

Affiliations

  • 1 Key Laboratory of Food Safety Research, Institute for Nutritional Sciences (INS), Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS), Shanghai, China; University of the Chinese Academy of Sciences, CAS, Beijing, China; Key Laboratory of Food Safety Risk Assessment, Ministry of Health, Beijing, China.
  • 2 Key Laboratory of Food Safety Research, Institute for Nutritional Sciences (INS), Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS), Shanghai, China; University of the Chinese Academy of Sciences, CAS, Beijing, China; Key Laboratory of Food Safety Risk Assessment, Ministry of Health, Beijing, China; School of Life Science and Technology, ShanghaiTech University, Shanghai, China. Electronic address: hyyin@sibs.ac.cn.
PMID: 25598486 DOI: 10.1016/j.redox.2014.12.011
Abstract

Oxidative stress-induced lipid peroxidation has been associated with human physiology and diseases including Cancer. Overwhelming data suggest that reactive lipid mediators generated from this process, such as 4-hydroxynonenal (4-HNE), are biomarkers for oxidative stress and important players for mediating a number of signaling pathways. The biological effects of 4-HNE are primarily due to covalent modification of important biomolecules including proteins, DNA, and Phospholipids containing amino group. In this review, we summarize recent progress on the role of 4-HNE in pathogenesis of Cancer and focus on the involvement of mitochondria: generation of 4-HNE from oxidation of mitochondria-specific phospholipid cardiolipin; covalent modification of mitochondrial proteins, lipids, and DNA; potential therapeutic strategies for targeting mitochondrial ROS generation, lipid peroxidation, and 4-HNE.

Keywords

4-HNE; Cancer; Cardiolipin; Free radicals; Lipid peroxidation; Mitochondria.

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