2. Academic Validation
  3. Lung resided monocytic myeloid-derived suppressor cells contribute to premetastatic niche formation by enhancing MMP-9 expression

Lung resided monocytic myeloid-derived suppressor cells contribute to premetastatic niche formation by enhancing MMP-9 expression

  • Mol Cell Probes. 2020 Apr;50:101498. doi: 10.1016/j.mcp.2019.101498.
Juechao Zhang 1,  Xiaoqing Han 2,  Huifang Shi 2,  Yanyan Gao 3,  Xuan Qiao 2,  Huihan Li 2,  Min Wei 4,  Xianlu Zeng 5
Affiliations

Affiliations

  • 1 The Key Laboratory of Molecular Epigenetics of MOE, Institute of Genetics and Cytology, Northeast Normal University, Changchun, China; Jilin University, Changchun, China.
  • 2 The Key Laboratory of Molecular Epigenetics of MOE, Institute of Genetics and Cytology, Northeast Normal University, Changchun, China.
  • 3 Jilin Agricultural University, Changchun, China.
  • 4 The Key Laboratory of Molecular Epigenetics of MOE, Institute of Genetics and Cytology, Northeast Normal University, Changchun, China. Electronic address: weim750@nenu.edu.cn.
  • 5 The Key Laboratory of Molecular Epigenetics of MOE, Institute of Genetics and Cytology, Northeast Normal University, Changchun, China. Electronic address: zengx779@nenu.edu.cn.
PMID: 31891749 DOI: 10.1016/j.mcp.2019.101498
Abstract

In Cancer patients, the prevalence of myeloid-derived suppressor cells (MDSCs) is correlated with the degree of malignancy. In the present study, we investigated the role of circulating M-MDSCs in premetastatic niche formation using a mouse syngeneic tumor model and found that there was an increased frequency of M-MDSCs in the peripheral blood of tumor-bearing mice. M-MDSCs tracking and lung tissue histological analyses revealed that the malignant conditions promote the residence of circulating M-MDSCs and increased tumor cell arrest in the lungs. We further found that MMP-9 expression was increased in the circulating M-MDSCs and the administration of an MMP-9 Inhibitor suppressed M-MDSCs transplantation-induced tumor cell arrest in the lung. Therefore, our findings suggest that the expansion of circulating M-MDSCs during tumor progression contributes to premetastatic niche formation by increasing MMP-9 expression.

Keywords

Matrix metalloprotein 9; Metastasis; Monocytic myeloid-derived suppressor cells; Pre-metastatic niche; Tumor progression.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-12354
    99.59%, MMP2/9 抑制剂
    MMP
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