1. Academic Validation
  2. Lycopene attenuates body weight gain through induction of browning via regulation of peroxisome proliferator-activated receptor γ in high-fat diet-induced obese mice

Lycopene attenuates body weight gain through induction of browning via regulation of peroxisome proliferator-activated receptor γ in high-fat diet-induced obese mice

  • J Nutr Biochem. 2020 Apr;78:108335. doi: 10.1016/j.jnutbio.2019.108335.
Ruyuan Zhu 1 Junping Wei 2 Haixia Liu 1 Chenyue Liu 1 Lili Wang 1 Beibei Chen 1 Lin Li 1 Qiangqiang Jia 1 Yimiao Tian 1 Rui Li 1 Dandan Zhao 1 Fangfang Mo 1 Yu Li 3 Sihua Gao 1 Xiang-Dong Wang 4 Dongwei Zhang 5
Affiliations

Affiliations

  • 1 Diabetes Research Center, Traditional Chinese Medicine School, Beijing University of Chinese Medicine, Beijing 100029, China.
  • 2 Guang'anmen Hospital, China Academy Sciences of Traditional Chinese Medicine, Beijing 100053, China.
  • 3 Department of Histology and Embryology, Beijing University of Chinese Medicine, Beijing 100029, China.
  • 4 Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA.
  • 5 Diabetes Research Center, Traditional Chinese Medicine School, Beijing University of Chinese Medicine, Beijing 100029, China. Electronic address: dongwei1006@gmail.com.
Abstract

Lycopene (LYC), one of the major carotenoids in tomatoes, has been preclinically and clinically used to obesity and type 2 diabetes management. However, whether its ability of countering body weight gain is related to induction of brown-like adipocyte phenotype in white adipose tissues (WAT) remains largely unknown. Activation of Peroxisome Proliferator-activated Receptor γ (PPARγ) serves the brown-like phenotype conversion and energy expenditure. Here, we show that LYC treatment promotes glucose consumption and improves Insulin sensitivity, as well as fosters white adipocytes browning through up-regulating mRNA and protein expression levels of PPARγ, uncoupling protein 1, PPARγ coactivator-1α and PR domain-containing 16 in the differentiated 3T3-L1 adipocytes and primary adipocytes, as well as in the WAT of HFD-exposed obese mice. In addition, LYC treatment attenuates body weight gain and improves serum lipid profiles as well as promotes brown adipose tissue activation in obese mice. Moreover, PPARγ is induced with LYC intervention in mitochondria respiration and browning in white adipocytes and tissues. Taken together, these results suggest that LYC counteracts obesity and improves glucose and lipid metabolism through induction of the browning via up-regulation of PPARγ, which offers a new perspective of this compound to combat obesity and obesity-related disorders.

Keywords

Brown adipose tissue; Lycopene; Obese mice; Peroxisome proliferator-activated receptor γ; White adipose tissue browning.

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