1. Academic Validation
  2. Discovery of phloroglucinols from Hypericum japonicum as ferroptosis inhibitors

Discovery of phloroglucinols from Hypericum japonicum as ferroptosis inhibitors

  • Fitoterapia. 2021 Sep;153:104984. doi: 10.1016/j.fitote.2021.104984.
Xing Peng 1 Qingyun Tan 1 Huihao Zhou 1 Jun Xu 1 Qiong Gu 2
Affiliations

Affiliations

  • 1 Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
  • 2 Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China. Electronic address: guqiong@mail.sysu.edu.cn.
Abstract

Ferroptosis is a new type of cell death, which involves central neuronal system. Inhibition of Ferroptosis is a promising strategy to prevent and treat neurological diseases. Thirteen phloroglucinols (1-13) were obtained from the whole Plants of Hypericum japonicum. Of them, compounds 1-3 are new ones. Their structures were elucidated by extensive analysis of spectroscopic data and X-ray diffraction. All the isolates were evaluated for their inhibitory effect on RSL3-induced Ferroptosis. Two new compounds 2-3 showed significant inhibitory effect with EC50 of 0.48 ± 0.14 μM and 0.94 ± 0.14 μM, respectively. DPPH free radical scavenging abilities of all compounds were assessed to evaluate their antioxidant effect. This work first reports the anti-ferroptosis activity of phloroglucinols.

Keywords

Antioxidant effect; Ferroptosis inhibitor; Hypericum japonicum; Phloroglucinols.

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