2. Academic Validation
  3. Neuraminidase 1 promotes renal fibrosis development in male mice

Neuraminidase 1 promotes renal fibrosis development in male mice

  • Nat Commun. 2023 Mar 27;14(1):1713. doi: 10.1038/s41467-023-37450-8.
Qian-Qian Chen # 1 2,  Kang Liu # 3,  Ning Shi # 4,  Gaoxiang Ma 5,  Peipei Wang 6,  Hua-Mei Xie 5,  Si-Jia Jin 4,  Ting-Ting Wei 1,  Xiang-Yu Yu 1,  Yi Wang 5,  Jun-Yuan Zhang 1,  Ping Li 1,  Lian-Wen Qi 7 8 9,  Lei Zhang 10 11
Affiliations

Affiliations

  • 1 State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China.
  • 2 School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
  • 3 Department of Nephrology, Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
  • 4 School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 211198, China.
  • 5 Clinical Metabolomics Center, China Pharmaceutical University, Nanjing, 211198, China.
  • 6 College of Food Science and Technology, Shanghai Ocean University, Shanghai, 201306, China.
  • 7 State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China. Qilw@cpu.edu.cn.
  • 8 School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 211198, China. Qilw@cpu.edu.cn.
  • 9 Clinical Metabolomics Center, China Pharmaceutical University, Nanjing, 211198, China. Qilw@cpu.edu.cn.
  • 10 State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China. Zhanglei@cpu.edu.cn.
  • 11 School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 211198, China. Zhanglei@cpu.edu.cn.
  • # Contributed equally.
PMID: 36973294 DOI: 10.1038/s41467-023-37450-8
Abstract

The functions of the Influenza Virus Neuraminidase has been well documented but those of the mammalian neuraminidases remain less explored. Here, we characterize the role of neuraminidase 1 (NEU1) in unilateral ureteral obstruction (UUO) and folic acid (FA)-induced renal fibrosis mouse models. We find that NEU1 is significantly upregulated in the fibrotic kidneys of patients and mice. Functionally, tubular epithelial cell-specific NEU1 knockout inhibits epithelial-to-mesenchymal transition, inflammatory cytokines production, and collagen deposition in mice. Conversely, NEU1 overexpression exacerbates progressive renal fibrosis. Mechanistically, NEU1 interacts with TGFβ type I receptor ALK5 at the 160-200aa region and stabilizes ALK5 leading to SMAD2/3 activation. Salvianolic acid B, a component of Salvia miltiorrhiza, is found to strongly bind to NEU1 and effectively protect mice from renal fibrosis in a NEU1-dependent manner. Collectively, this study characterizes a promotor role for NEU1 in renal fibrosis and suggests a potential avenue of targeting NEU1 to treat kidney diseases.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z