2. Academic Validation
  3. Systemic administration of Shikonin ameliorates cognitive impairment and neuron damage in NPSLE mice

Systemic administration of Shikonin ameliorates cognitive impairment and neuron damage in NPSLE mice

  • J Neuroimmunol. 2023 Jul 28;382:578166. doi: 10.1016/j.jneuroim.2023.578166.
Jiali Ni 1,  Xuan Liu 1,  Ruowen Zhang 1,  Hailin Wang 1,  Jun Liang 2,  Yayi Hou 3,  Huan Dou 4
Affiliations

Affiliations

  • 1 The State Key Laboratory of Pharmaceutical Biotechnology, Division of Immunology, Medical School, Nanjing University, Nanjing 210093, PR China; Jiangsu Key Laboratory of Molecular Medicine, Nanjing 210093, PR China.
  • 2 Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China.
  • 3 The State Key Laboratory of Pharmaceutical Biotechnology, Division of Immunology, Medical School, Nanjing University, Nanjing 210093, PR China; Jiangsu Key Laboratory of Molecular Medicine, Nanjing 210093, PR China. Electronic address: yayihou@nju.edu.cn.
  • 4 The State Key Laboratory of Pharmaceutical Biotechnology, Division of Immunology, Medical School, Nanjing University, Nanjing 210093, PR China; Jiangsu Key Laboratory of Molecular Medicine, Nanjing 210093, PR China. Electronic address: douhuan@nju.edu.cn.
PMID: 37536051 DOI: 10.1016/j.jneuroim.2023.578166
Abstract

Shikonin is an anti-inflammatory natural herbal drug extracted from Lithospermum erythrorhizon and its therapeutic effect on neuropsychiatric systemic lupus erythematosus (NPSLE) is yet unknown. In our study, Shikonin significantly reversed the cognitive impairment and alleviated the brain tissue damage in NPSLE mice. The permeability of blood-brain barrier was also verified to be repaired in Shikonin-treated NPSLE mice. In particular, we found that Shikonin alleviated neuroinflammation through inhibiting β-catenin signaling pathway, thereby depressing the activation of microglia and the loss of neuronal synapses. Overall, Shikonin may be a promising candidate drug for NPSLE through diminishing neuroinflammation and repairing neuron damage.

Keywords

Cognition; Neuron; Neuropsychiatric systemic lupus erythematosus; Shikonin.

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