2. Academic Validation
  3. Piperidine: A Versatile Heterocyclic Ring for Developing Monoamine Oxidase Inhibitors

Piperidine: A Versatile Heterocyclic Ring for Developing Monoamine Oxidase Inhibitors

  • ACS Omega. 2023 Oct 3;8(41):37731-37751. doi: 10.1021/acsomega.3c05883.
Jayalakshmi Jayan 1,  Namitha Chandran 1,  Amrutha Chandran Thekkantavida 1,  Mohamed A Abdelgawad 2 3,  Mohammed M Ghoneim 4,  Mohamed E Shaker 5 6,  Prerna Uniyal 7,  Feba Benny 1,  Subin Mary Zachariah 1,  Sunil Kumar 1,  Hoon Kim 8,  Bijo Mathew 1
Affiliations

Affiliations

  • 1 Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, Kerala 682 041 India.
  • 2 Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka 72341, Saudi Arabia.
  • 3 Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Beni Suef University, Beni Suef 2722165, Egypt.
  • 4 Department of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Ad Diriyah 13713, Saudi Arabia.
  • 5 Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka 72341, Aljouf Saudi Arabia.
  • 6 Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.
  • 7 School of Pharmacy, Graphic Era Hill University, Dehradun 248002, Uttarakhand, India.
  • 8 Department of Pharmacy, Research Institute of Life Pharmaceutical Sciences, Sunchon National University, Suncheon 57922, Republic of Korea.
PMID: 37867639 DOI: 10.1021/acsomega.3c05883
Abstract

The Monoamine Oxidase enzyme (MAO), which is bound on the membrane of mitochondria, catalyzes the oxidative deamination of endogenous and exogenous monoamines, including monoamine neurotransmitters such as serotonin, adrenaline, and dopamine. These enzymes have been proven to play a significant role in neurodegeneration; thus, they have recently been researched as prospective therapeutic targets for neurodegenerative illness treatment and management. MAO inhibitors have already been marketed as neurodegeneration illness treatments despite their substantial side effects. Hence, researchers are concentrating on developing novel molecules with selective and reversible inhibitory properties. Piperine, which is a phytochemical component present in black pepper, has been established as a potent MAO inhibitor. Piperine encompasses a piperidine nucleus with Antibacterial, anti-inflammatory, antihypertensive, anticonvulsant, antimalarial, Antiviral, and Anticancer properties. The current Review focuses on the structural changes and structure-activity relationships of piperidine derivatives as MAO inhibitors.

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