2. Academic Validation
  3. The naringin/carboxymethyl chitosan/sodium hyaluronate/silk fibroin scaffold facilitates the healing of diabetic wounds by restoring the ROS-related dysfunction of vascularization and macrophage polarization

The naringin/carboxymethyl chitosan/sodium hyaluronate/silk fibroin scaffold facilitates the healing of diabetic wounds by restoring the ROS-related dysfunction of vascularization and macrophage polarization

  • Int J Biol Macromol. 2024 Jan 12:129348. doi: 10.1016/j.ijbiomac.2024.129348.
Hao Yang 1,  Hailin Xu 1,  Dongming Lv 1,  Shuting Li 2,  Yanchao Rong 1,  Zhiyong Wang 1,  Peng Wang 1,  Xiaoling Cao 1,  Xiaohui Li 1,  Zhongye Xu 1,  Bing Tang 3,  Jiayuan Zhu 4,  Zhicheng Hu 5
Affiliations

Affiliations

  • 1 First Affiliated Hospital of Sun Yat-sen University, Department of Burn and Wound Repair, Guangzhou, China.
  • 2 First Affiliated Hospital of Sun Yat-sen University, Department of Plastic Surgery, Guangzhou, China.
  • 3 First Affiliated Hospital of Sun Yat-sen University, Department of Burn and Wound Repair, Guangzhou, China. Electronic address: tangbing@mail.sysu.edu.cn.
  • 4 First Affiliated Hospital of Sun Yat-sen University, Department of Burn and Wound Repair, Guangzhou, China. Electronic address: zhujiay@mail.sysu.edu.cn.
  • 5 First Affiliated Hospital of Sun Yat-sen University, Department of Burn and Wound Repair, Guangzhou, China. Electronic address: huzhch5@mail.sysu.edu.cn.
PMID: 38219943 DOI: 10.1016/j.ijbiomac.2024.129348
Abstract

Chronic diabetic wounds remain a globally recognized clinical challenge, which occurs mainly due to the disturbances of wound microenvironmental induced by high concentrations of Reactive Oxygen Species (ROS). Impairments in angiogenesis and inflammation in the wound microenvironment ultimately impede the normal healing process. Therefore, targeting macrophage and vascular endothelial cell dysfunction is a promising therapeutic strategy. In our study, we fabricated artificial composite scaffolds composed of naringin/carboxymethyl chitosan/sodium hyaluronate/silk fibroin (NG/CMCS/HA/SF) to promote wound healing. The NG/CMCS/HA/SF scaffold demonstrated favorable anti-inflammatory, anti-oxidative, and pro-angiogenic properties in both in vitro and in vivo experiments, effectively promoting the healing of diabetic wounds. The positive therapeutic effects observed indicate that the composite scaffolds have great potential in clinical wound healing applications.

Keywords

Composite scaffold; Diabetic wound healing; Macrophage; Reactive oxygen species (ROS); Vascularization.

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