2. Membrane Transporter/Ion Channel
  3. Monocarboxylate Transporter P-glycoprotein
  4. MCT1-IN-3

MCT1-IN-3 是一种单羧酸转运蛋白 1 (MCT1) 抑制剂，IC50 值为 81.0 nM。MCT1-IN-3 还对多药转运蛋白 ABCB1 具有显著的抑制作用。MCT1-IN-3 可用于癌症的研究。

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MCT1-IN-3 Chemical Structure

MCT1-IN-3 Chemical Structure

CAS No. : 2878360-80-4

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规格 价格 是否有货 数量
1 mg ￥2208
1 周
5 mg   询价  
10 mg   询价  

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MCT1-IN-3 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MCT1-IN-3 is a monocarboxylate transporter 1 (MCT1) inhibitor with an IC50 value of 81.0 nM. MCT1-IN-3 has also significant inhibitivity against the multidrug transporter ABCB1. MCT1-IN-3 can be used for the research of cancer[1].

IC50 & Target

IC50: 81.0 nM (MCT1)[1]
GI50: 20 μM (A-549); 15.1 μM (MCF-7)[1]
体外研究
(In Vitro)

MCT1-IN-3 (compound 24) 对 MCT1 具有抑制活性，IC50 值为 81.0 nM[1]。
MCT1-IN-3 对表达 MCT1 的癌细胞系 A-549 和 MCF-7 具有很强的抗增殖活性，GI50 值分别为 20 μM 和 15.1 μM[1]< /sup>.
MCT1-IN-3（5 μM；24 h）导致癌细胞周期停滞和细胞凋亡[1]。
MCT1-IN-3（1.0、2.0、3.5 和 5.0 μM）显示可使这些癌细胞对抗肿瘤药物敏感[1]。
MCT1-IN-3 还对多药转运蛋白 ABCB1 具有显著的抑制作用，并显示可逆转 ABCB1 介导的多药耐药性 (MDR) [1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MCT1-IN-3 相关抗体:

Cell Cycle Analysis[1]

Cell Line: A-549 cells
Concentration: 5 μM
Incubation Time: 24 h
Result: Caused a disruption of the cell cycle of A-549 cancer cells, indicated by a shift from the predominant Go/G, phase.

Apoptosis Analysis[1]

Cell Line: A-549 cells
Concentration: 5 μM
Incubation Time: 24 h
Result: Increased the percentage of total apoptotic cells by a factor of 13 from 0.51 to 6.68%.
分子量

389.40

Formula

C22H19N3O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MCT1-IN-3 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MCT1-IN-32878360-80-4Monocarboxylate TransporterP-glycoproteinP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243monocarboxylate transporter 1 (MCT1)multidrug transportercancerInhibitorinhibitorinhibit

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产品名称：
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目录号：
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