2. GPCR/G Protein
  3. Adenosine Receptor
  4. MRS1220

MRS1220 是一种高效、选择性的人 A3 腺苷受体 (hA3AR) 拮抗剂，Ki 为 0.59 nM，可用于中枢神经系统疾病的研究。MRS1220 在体内还减少了胶质母细胞瘤的肿瘤大小和血管形成。

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MRS1220 Chemical Structure

MRS1220 Chemical Structure

CAS No. : 183721-15-5

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     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥1090
In-stock
5 mg ￥2400
In-stock
10 mg ￥3800
In-stock
25 mg ￥7600
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

MRS1220 相关抗体

Top Publications Citing Use of Products

查看 Adenosine Receptor 亚型特异性产品:

查看所有亚型
Adenosine A1 receptor (A1R) Adenosine A2A receptor (A2AR) Adenosine A2B receptor (A2BR) Adenosine A3 receptor (A3R)

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MRS1220, a highly potent and selective human A3 adenosine receptor (hA3AR) antagonist with a Ki of 0.59 nM, has therapeutic potential for the research of diseases of the central nervous system[1]. MRS1220 reduces glioblastoma tumor size and blood vessel formation in vivo[2].

体外研究
(In Vitro)

MRS 1220 reverses the effect of A3 agonist-elicited inhibition of tumor necrosis factor-α formation in the human macrophage U-937 cell line with an IC50 of 0.3 μM[1].
VEGF secretion in U87MG glioblastoma stem-like cells (GSCs) decreases ~25% with MRS1220 after 72 h of hypoxia[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MRS1220 相关抗体:

Cell Viability Assay[2]

Cell Line: U87MG GSCs
Concentration: 10 μM
Incubation Time: 72 hours
Result: Decreased ~25% VEGF secretion.
体内研究
(In Vivo)

MRS1220 (0.15 mg/kg; intraperitoneal inoculation) reduces tumor size and blood vessel formation in vivo. MRS1220 exhibits a strong in vivo anti-angiogenic effect[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Eight, 8 week-old male Sprague-Dawley rats bearing C6 (GSCs)[2]
Dosage: 0.15 mg/kg/72 h
Administration: Administered by intraperitoneal inoculation, for fifteen days
Result: A reduction close to 80% and 90% in tumor volume compared to the vehicle-treated group at day ten and fifteen post-treatment, respectively.
分子量

403.82

Formula

C21H14ClN5O2
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 4 mg/mL (9.91 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.4764 mL 12.3818 mL 24.7635 mL
5 mM 0.4953 mL 2.4764 mL 4.9527 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

MRS1220 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4764 mL 12.3818 mL 24.7635 mL 61.9088 mL
5 mM 0.4953 mL 2.4764 mL 4.9527 mL 12.3818 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MRS1220183721-15-5MRS 1220MRS-1220Adenosine ReceptorP1 receptorA3adenosinereceptorhA3ARdiseasescentralnervoussystemglioblastomatumorsizebloodvesselformationInhibitorinhibitorinhibit

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产品名称：
MRS1220
目录号：
HY-103190
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