2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. Ned 19

Ned 19 是一种选择性膜透性非竞争性 NAADP 拮抗剂，抑制 NAADP 介导的 Ca2+ 信号传导，IC50 为 65 nM。 Ned 19 强烈抑制小鼠的肿瘤生长和血管形成以及肺转移。

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Ned 19 Chemical Structure

Ned 19 Chemical Structure

CAS No. : 874374-25-1

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥1925
In-stock
5 mg ￥1700
In-stock
10 mg ￥2600
In-stock
25 mg ￥4290
In-stock
50 mg ￥6006
In-stock
100 mg ￥8408
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Ned 19:

Ned 19 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ned 19 is a selective membrane-permeant non competitive NAADP antagonist and inhibits NAADP-mediated Ca2+ signaling, with an IC50 of 65 nM[1]. Ned 19 strongly inhibits tumor growth and vascularization as well as lung metastases in mice[2].

IC50 & Target

NAADP, Ca2+[1]
体外研究
(In Vitro)

Ned 19 (25-100 μM; 24-72 hours) reduces cell proliferation[2].
Ned 19 (25-100 μM; 24-72 hours) reduces markedly the cell number[2].
Ned 19 (25-100 μM; 24-72 hours) reduces the S phase percentage and increases of the G0/G1 phase percentage evaluated by cell cycle analysis[2].
Ned 19 (25-100 μM; 24-72 hours) induces cell apoptosis a time-dependent manner[2].
Ned 19 (25-100 μM; 24-72 hours) reduces expression of N-cadherin and increases expression of E-cadherin, affecting the cell migratory behavior[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ned 19 相关抗体:

Cell Proliferation Assay[2]

Cell Line: B16 cells
Concentration: 25, 50, 100 μM
Incubation Time: 24, 48, 72 hours
Result: Reduced cell proliferation.

Cell Viability Assay[2]

Cell Line: B16 cells
Concentration: 25, 50, 100 μM
Incubation Time: 24, 48, 72 hours
Result: Reduced markedly the cell number.

Cell Cycle Analysis[2]

Cell Line: B16 cells
Concentration: 25, 50, 100 μM
Incubation Time: 24, 48, 72 hours
Result: Reduced the S phase percentage and increased of the G0/G1 phase percentage.

Apoptosis Analysis[2]

Cell Line: B16 cells
Concentration: 25, 50, 100 μM
Incubation Time: 24, 48, 72 hours
Result: Induced cell apoptosis a time-dependent manner.

Western Blot Analysis[2]

Cell Line: B16 cells
Concentration: 25, 50, 100 μM
Incubation Time: 24, 48, 72 hours
Result: Reduced expression of N-cadherin and increased expression of E-cadherin.
体内研究
(In Vivo)

Ned 19 (i.p.; 5 mg/Kg/every second day; 4 week) impaires severely tumor growth[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male C57BL/6 mice[2]
Dosage: 5 mg/Kg
Administration: I.p.; every second day; 4 week
Result: Impaired severely tumor growth.
分子量

514.59

Formula

C30H31FN4O3
CAS 号
性状

固体

颜色

Off-white to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 125 mg/mL (242.91 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.9433 mL 9.7165 mL 19.4329 mL
5 mM 0.3887 mL 1.9433 mL 3.8866 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.92%

COA (200 KB) HNMR (277 KB) RP-HPLC (244 KB) MS (70 KB)

产品使用指南 (1538 KB)
参考文献

Ned 19 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9433 mL 9.7165 mL 19.4329 mL 48.5824 mL
5 mM 0.3887 mL 1.9433 mL 3.8866 mL 9.7165 mL
10 mM 0.1943 mL 0.9716 mL 1.9433 mL 4.8582 mL
15 mM 0.1296 mL 0.6478 mL 1.2955 mL 3.2388 mL
20 mM 0.0972 mL 0.4858 mL 0.9716 mL 2.4291 mL
25 mM 0.0777 mL 0.3887 mL 0.7773 mL 1.9433 mL
30 mM 0.0648 mL 0.3239 mL 0.6478 mL 1.6194 mL
40 mM 0.0486 mL 0.2429 mL 0.4858 mL 1.2146 mL
50 mM 0.0389 mL 0.1943 mL 0.3887 mL 0.9716 mL
60 mM 0.0324 mL 0.1619 mL 0.3239 mL 0.8097 mL
80 mM 0.0243 mL 0.1215 mL 0.2429 mL 0.6073 mL
100 mM 0.0194 mL 0.0972 mL 0.1943 mL 0.4858 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ned 19874374-25-1Ned19Ned-19Calcium ChannelCa2+ channelsCa channelsInhibitorinhibitorinhibit

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