2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. Oxyphencyclimine

Oxyphencyclimine 是一种口服有效的毒蕈碱受体拮抗剂。Oxyphencyclimine 在胃溃疡动物模型中，能有效降低溃疡指数，同时增加胃蛋白酶活性。Oxyphencyclimine 可用于消化性溃疡病和胃肠道痉挛的研究。

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Oxyphencyclimine Chemical Structure

Oxyphencyclimine Chemical Structure

CAS No. : 125-53-1

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Oxyphencyclimine 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Oxyphencyclimine is an orally active muscarinic receptor (mAChR) antagonist. Oxyphencyclimine is effective in reducing ulceration index and increasing pepsin activity in rat gastric ulcer model. Oxyphencyclimine can be used in studies of peptic ulcer disease and gastrointestinal spasm[1][2].

体内研究
(In Vivo)

Oxyphencyclimine (10 mg/kg; p.o.; single) reduces ulceration index and increases pepsin activity in rat gastric ulcer model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male or female Sprague-Dawley rats (160-170 g; Reserpine or Phenylbutazone-induced rat gastric ulcer model)[1].
Dosage: 10 mg/kg
Administration: Oral administration; single.
Result: Increased pepsin activity in Reserpine-induced gastric ulcer rat from 5.9% (1 % homogenate) and 9.0% (supernatant) to 9.7% and 18.4%, respectively.
Increased pepsin activity in Phenylbutazone-induced gastric ulcer rat from 13.0% (1 % homogenate) and 26.1% (supernatant) to 21.3% and 43.6%, respectively.
Decreased rate of ulcers in Reserpine and Phenylbutazone-induced rat gastric ulcer model from 93% and 100 % to 38% and 60%, respectively.
分子量

344.45

Formula

C20H28N2O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Oxyphencyclimine 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Oxyphencyclimine125-53-1mAChRMuscarinic acetylcholine receptorpeptic ulcer diseasegastrointestinal spasmpepsinInhibitorinhibitorinhibit

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