PACAP (1-38) free acid 

PACAP (1-38) free acid is an endogenous neuropeptide. PACAP (1-38) free acid potently stimulates antral motility and somatostatin secretion, inhibits the secretion of gastrin and stimulates the release of vasoactive intestinal polypeptide, gastrin releasing peptide and substance P. PACAP (1-38) free acid also enhances N-methyl-D-aspartate receptor function and expression of brain-derived neurotrophic factor through RACK1^[1][2].

PACAP (1-38) free acid (1 nM) 增加 P 物质、胃泌素释放肽和血管活性肠肽的释放^[1]。
PACAP (1-38) free acid (100 nM; 10 min) 诱导大鼠海马切片中 NR2B 的酪氨酸磷酸化^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

4535.24

C₂₀₃H₃₃₀N₆₂O₅₄S

129405-61-4

His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-Gly-Lys-Arg-Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys

HSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNK

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Tornøe K, et al. PACAP 1-38 as neurotransmitter in the porcine antrum. Regul Pept. 2001 Sep 15;101(1-3):109-21.  [Content Brief]

  [2]. Yaka R, et al. Pituitary adenylate cyclase-activating polypeptide (PACAP(1-38)) enhances N-methyl-D-aspartate receptor function and brain-derived neurotrophic factor expression via RACK1. J Biol Chem. 2003 Mar 14;278(11):9630-8.  [Content Brief]