2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. PARP Caspase Apoptosis
  4. PARP1-IN-17

PARP1-IN-17 是 PARP-1 抑制剂 (PARP-1 IC50 = 19.24 nM，PARP-2 IC50 = 32.58 nM)，可诱导细胞凋亡(apoptosis)。PARP1-IN-17 具有良好的抗增殖活性。

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PARP1-IN-17 Chemical Structure

PARP1-IN-17 Chemical Structure

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PARP1-IN-17 相关抗体

Top Publications Citing Use of Products

查看 PARP 亚型特异性产品:

查看所有亚型
PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

查看 Caspase 亚型特异性产品:

查看所有亚型
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PARP1-IN-17 is a PARP-1 inhibitor (IC50 = 19.24 nM for PARP-1 and = 32.58 nM for PARP-2) and induce apoptosis. PARP1-IN-17 shows excellent anti-proliferative activity[1].

IC50 & Target

PARP-1

 

Caspase 3

 

体外研究
(In Vitro)

PARP1-IN-17 (Compound 11b) (72 小时) 对 A549 细胞，OVCAR-3 细胞，HCT-116 细胞和 MCF-7 细胞具有抑制增殖作用[1]。
PARP1-IN-17 (1-4 μM, 48 h) 可减少 PAR 的生物合成，诱导 A549 细胞凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PARP1-IN-17 相关抗体:

Cell Proliferation Assay[1]

Cell Line: A549 cells, OVCAR-3 cells, HCT-116 cells, MCF-7 cells
Concentration:
Incubation Time: 72 h
Result: Had excellent anti-proliferative activity against A549 cell, OVCAR-3 cells, HCT-116 cells and MCF-7 cells (IC50=1.95 ± 0.33 µM, 4.02 ± 0.24 µM, 7.45 ± 1.98 µM and 9.21 ± 2.54 µM).

Apoptosis Analysis[1]

Cell Line: A549 cells
Concentration: 1 μM, 2 μM, 4 μM
Incubation Time: 48 h
Result: Induced apoptosis in cancer cells and increased the apoptosis rates of A549 cells in a dose-dependent manner.

Western Blot Analysis[1]

Cell Line: A549 cells, OVCAR-3 cells, HCT-116 cells, MCF-7 cells
Concentration: 1 μM, 2 μM, 4 μM
Incubation Time:
Result: Reduced the biosynthesis of PAR, and had the best effect at 4.0 µM.
Decreased the expression of Caspase 3.
分子量

406.50

Formula

C24H27FN4O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PARP1-IN-17 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PARP1-IN-17PARPCaspaseApoptosispoly ADP ribose polymerase A549 cellsOVCAR-3 cellsHCT-116 cellsMCF-7 cellsAnti-proliferativeInhibitorinhibitorinhibit

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