2. Anti-infection
  3. HSV
  4. Pritelivir mesylate hydrate

Pritelivir mesylate hydrate  (Synonyms: AIC316 mesylate hydrate; BAY 57-1293 mesylate hydrate)

目录号: HY-15303B 纯度: 99.51%
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摩尔计算器

Pritelivir mesylate hydrate (BAY 57-1293 mesylate hydrate) 是一种病毒解旋酶-引物酶复合物 (helicase-primase complex) 抑制剂，在体外和单纯疱疹病毒 (HSV) 感染的动物模型中均具有抗病毒活性。Pritelivir mesylate hydrate 对 1 型和 2 型单纯疱疹病毒 (HSV-1 和 HSV-2) 具有活性，对 HSV1-2 的 IC50 为 0.02 μM。

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Pritelivir mesylate hydrate Chemical Structure

Pritelivir mesylate hydrate Chemical Structure

CAS No. : 1428321-10-1

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规格 价格 是否有货 数量
5 mg ￥500
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10 mg ￥700
In-stock
50 mg ￥1500
In-stock
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Pritelivir mesylate hydrate 相关抗体

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  • 生物活性

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生物活性

Pritelivir mesylate hydrate (BAY 57-1293 mesylate hydrate), an inhibitor of the viral helicase-primase complex, exhibits antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection. Pritelivir mesylate hydrate is active against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) with the IC50 of 0.02 μM against HSV1-2[1].

IC50 & Target[1]

HSV-1

0.02 μM (IC50)

HSV-2

0.02 μM (IC50)

体内研究
(In Vivo)

Pritelivir is the first in a class of antiviral agents that inhibit HSV replication by targeting the viral helicase–primase enzyme complex[2].
Pritelivir (0.03-45 mg/kg) significantly increases survival. Pritelivir (0.3-30 mg/kg) reduces mortality against HSV-1, E-377. Pritelivir has potent and resistance-breaking antiviral efficacy with potential for the treatment of potentially life-threatening HSV type 1 and 2 infections, including herpes simplex encephalitis[3].
Combination therapies of Pritelivir at 0.1 or 0.3 mg/kg/dose with Acyclovir (10 mg/kg/dose) are protective when compared to the vehicle treated group against HSV-2, strain MS[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c mice[3]
Dosage: 0.03 to 45 mg/kg
Administration: Administered orally, twice daily at approximately 12 h intervals, for 7 days
Result: Survival was significantly increased to 80-100% as compared to the vehicle treatment. Even the lowest dose of 0.3 mg/kg was effective in increasing survival to 53%.
Clinical Trial
分子量

516.61

Formula

C19H24N4O7S3
CAS 号
性状

固体

颜色

White to light yellow

中文名称

普瑞利韦甲磺酸盐一水合物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料
参考文献

Pritelivir mesylate hydrate 相关分类

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pritelivir mesylate1428321-10-1AIC316 mesylateBAY 57-1293 mesylate普瑞利韦甲磺酸盐一水合物HSVHerpes simplex virusviralhelicaseprimasecomplexherpesvirusHSV-1HSV-2Inhibitorinhibitorinhibit

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目录号：
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