2. Apoptosis Stem Cell/Wnt Anti-infection
  3. Bacterial Apoptosis Wnt Fungal Parasite
  4. Prodigiosin

Prodigiosin  (Synonyms: 灵菌红素; Prodigiosine; NSC47147)

目录号: HY-100711 纯度: 98.53%
COA 产品使用指南

摩尔计算器

Prodigiosin (Prodigiosine)，一种天然的红色素，是一种具有生物活性的次生代谢产物。Prodigiosin 是 Wnt/β-catenin 途径的有效抑制剂。Prodigiosin 具有抗菌，抗真菌，抗原生动物，抗疟疾，免疫抑制和抗癌特性。

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Prodigiosin Chemical Structure

Prodigiosin Chemical Structure

CAS No. : 82-89-3

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规格 价格 是否有货 数量
100 μg ￥700
In-stock
250 μg ￥1260
In-stock
500 μg ￥2100
In-stock
1 mg ￥3360
In-stock
5 mg   询价  
10 mg   询价  

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Customer Review

Other Forms of Prodigiosin:

Prodigiosin 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 Parasite 亚型特异性产品:

查看所有亚型
Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Prodigiosin (Prodigiosine) is a red pigment produced by bacteria as a bioactive secondary metabolite. Prodigiosin is a potent inhibitor of the Wnt/β-catenin pathway. Prodigiosin has antibacterial, antifungal, antiprotozoal, antimalarial, immunosuppressive, and anticancer properties[1][2].

IC50 & Target

Plasmodium

 

体外研究
(In Vitro)

Prodigiosin (25-500 nM; 24 hours) treatment reduces the viability of breast cancer cells, with IC50 values at 48 h of 62.52 nM in MDA-MB-231 cells and 261.2 nM in MDA-MB-468 cells[1].
Prodigiosin (25-500 nM; 24 hours) treatment significantly reduces the levels of phosphorylated LRP6 and DVL2, active β-catenin, and total β-catenin. Prodigiosin noticeably inhibits the phosphorylation of GSK3β at Ser9 in HEK293T cells, which is indicative of an increase in GSK3β activity[1].
Prodigiosin can inhibit proliferation and induce apoptosis in breast cancer cells[1].
Prodigiosin (25-500 nM; 24 hours) treatment dose-dependently blocks Wnt signaling activated by Wnt1, Wnt3, Wnt1/LRP6, Wnt3/LRP6, and Dishevelled 2 (DVL2) in transfected HEK293T cells. Prodigiosin treatment inhibits Wnt3A-CM-induced transcription in a dose-dependent manner. Prodigiosin inhibits transcription of the SuperTopFlash reporter activated by either Wnt transfection or Wnt3A treatment[1].
When applied to cultures of chytrid fungi Batrachochytrium dendrobatidis and B. salamandrivorans, Prodigiosin causes significant growth inhibition, with MIC values of 10 μM and 50 μM, respectively[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Prodigiosin 相关抗体:

Cell Proliferation Assay[1]

Cell Line: MDA-MB-231 and MDA-MB-468 cells
Concentration: 10 nM, 25 nM, 50 nM, 100 nM, 250 nM, 500 nM, 1000 nM, 2500 nM, 5000 nM
Incubation Time: 24 hours, 48 hours
Result: Reduced the viability of breast cancer cells, with IC50 values at 48 h of 62.52 nM in MDA-MB-231 cells and 261.2 nM in MDA-MB-468 cells.

Western Blot Analysis[1]

Cell Line: HEK293T cells
Concentration: 50 nM, 100 nM, 250 nM, 500 nM
Incubation Time: 24 hours
Result: Significantly reduced the levels of phosphorylated LRP6 and DVL2, active β-catenin, and total β-catenin.
体内研究
(In Vivo)

Prodigiosin (5 mg/kg; intraperitoneal injection; twice weekly; for 3 weeks) treatment significantly inhibits tumor growth. Prodigiosin treatment decreases tumor cell density and expression of the proliferation marker Ki-67[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c nude mice injected with MDA-MB-231 cells[1]
Dosage: 5 mg/kg
Administration: Intraperitoneal injection; twice weekly; for 3 weeks
Result: Significantly inhibited tumor growth in mice.
分子量

323.43

Formula

C20H25N3O
CAS 号
性状

固体

颜色

Brown to red

中文名称

灵菌红素
结构分类
初始来源

Serratia marcescens
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 25 mg/mL (77.30 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.0919 mL 15.4593 mL 30.9186 mL
5 mM 0.6184 mL 3.0919 mL 6.1837 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: ≥99.0%

COA (263 KB)

产品使用指南 (1538 KB)
参考文献

Prodigiosin 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0919 mL 15.4593 mL 30.9186 mL 77.2965 mL
5 mM 0.6184 mL 3.0919 mL 6.1837 mL 15.4593 mL
10 mM 0.3092 mL 1.5459 mL 3.0919 mL 7.7296 mL
15 mM 0.2061 mL 1.0306 mL 2.0612 mL 5.1531 mL
20 mM 0.1546 mL 0.7730 mL 1.5459 mL 3.8648 mL
25 mM 0.1237 mL 0.6184 mL 1.2367 mL 3.0919 mL
30 mM 0.1031 mL 0.5153 mL 1.0306 mL 2.5765 mL
40 mM 0.0773 mL 0.3865 mL 0.7730 mL 1.9324 mL
50 mM 0.0618 mL 0.3092 mL 0.6184 mL 1.5459 mL
60 mM 0.0515 mL 0.2577 mL 0.5153 mL 1.2883 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Prodigiosin82-89-3Prodigiosine NSC47147灵菌红素NSC47147NSC 47147NSC-47147BacterialApoptosisWntFungalParasiteAntibacterialantifungalantiprotozoalantimalarialimmunosuppressiveanticancerpigmentβ-cateninInhibitorinhibitorinhibit

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