2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Pronethalol hydrochloride

Pronethalol hydrochloride  (Synonyms: (±)-Pronethalo hydrochloride)

目录号: HY-B1238A
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摩尔计算器

Pronethalol ((±)-Pronethalo) 是一种非选择性的 β-肾上腺素 (β-adrenergic) 拮抗剂。 Pronethalol 是有效的 Sox2 表达抑制剂。Pronethalol 可预防和逆转洋地黄引起的室性心律失常，也可以限制脑动静脉畸形 (AVMs)。

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Pronethalol hydrochloride Chemical Structure

Pronethalol hydrochloride Chemical Structure

CAS No. : 51-02-5

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Pronethalol hydrochloride 的其他形式现货产品:

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Pronethalol hydrochloride 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

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α adrenergic receptor β adrenergic receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pronethalol ((±)-Pronethalo) is a non-selective β-adrenergic antagonist. Pronethalol is a potent inhibitor of Sox2 expression. Pronethalol protects against and to reverse Digitalis-induced ventricular arrhythmias, and limits the cerebral arteriovenous malformation (AVMs)[1][2].

IC50 & Target

β adrenergic receptor

 

体外研究
(In Vitro)

Pronethalol (2, 10, 20 μM) represses EGFP expression in a dose- and time-dependent manner in ReNcell VM cells. Pronethalol (10 μM; 2 days) reduces Sox2 expression to less than 10% after 2 days of treatment[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Pronethalol hydrochloride 相关抗体:
体内研究
(In Vivo)

Pronethalol (0.15 mg/g; daily; for 14 days) stabilizes endothelial differentiation, lumen formation and improves cerebral arteriovenous malformation (AVMs) in Mgp–/– mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

265.78

Formula

C15H20ClNO
CAS 号
中文名称

盐酸普罗纳赛洛；盐酸丙萘洛尔
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Pronethalol hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pronethalol51-02-5(±)-Pronethalo盐酸普罗纳赛洛盐酸丙萘洛尔Adrenergic ReceptorBeta ReceptorSox2expressionDigitalisventriculararrhythmiascerebralarteriovenousmalformationAVMsEGFPendothelialdifferentiationlumenformationInhibitorinhibitorinhibit

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