2. PROTAC Protein Tyrosine Kinase/RTK JAK/STAT Signaling Apoptosis
  3. PROTACs EGFR Apoptosis
  4. PROTAC EGFR degrader 6

PROTAC EGFR degrader 6 是一种 PROTAC EGFR 降解剂，可有效降解 HCC827 细胞中的 EGFRDel19，DC50 为 45.2 nM。PROTAC EGFR degrader 6 显著诱导 HCC827 细胞凋亡 (apoptosis) 并将细胞阻滞在 G1 期。

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PROTAC EGFR degrader 6 Chemical Structure

PROTAC EGFR degrader 6 Chemical Structure

CAS No. : 2409793-28-6

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PROTAC EGFR degrader 6 相关抗体

Top Publications Citing Use of Products

查看 PROTACs 亚型特异性产品:

查看所有亚型
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

查看 EGFR 亚型特异性产品:

查看所有亚型
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PROTAC EGFR degrader 6, a PROTAC EGFR degrader, potently degrades EGFRDel19 in HCC827 cells with the DC50 of 45.2 nM. PROTAC EGFR degrader 6 significantly induces the apoptosis of HCC827 cells and arrest the cells in G1 phase[1].

IC50 & Target

IC50: 180 nM (EGFRDel19 in HCC827 cells)[1]
DC50: 45.2 nM (EGFRDel19 in HCC827 cells)[1]
体外研究
(In Vitro)

PROTAC EGFR degrader 6 (compound 2) (0.001-10 μM; 48 hours) exhibits potent EGFR degradation activity with certain concentration-dependent manner; and shows DC50 of 45.2 nM in HCC827 cells[1].
PROTAC EGFR degrader 6 (100 nM; 4-96 hours) degradates EGFR protein in a time-dependent manner, and reaches the maximum degradation rate (Dmax = 87%) at 96 h[1].
PROTAC EGFR degrader 6 (0.1, 1 and 10 μM; 48 hours) shows weak degradation activity on EGFR in H1975 and A549 cells[1].
PROTAC EGFR degrader 6 (0.1 and 1 μM; 32 hours) induce HCC827 apoptosis, and the percentages of apoptosis cells are 53.72% and 32.31% at 0.1 and 1 μM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PROTAC EGFR degrader 6 相关抗体:
分子量

913.05

Formula

C49H57FN12O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PROTAC EGFR degrader 6 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC EGFR degrader 62409793-28-6PROTAC EGFR degrader6PROTAC EGFR degrader-6PROTACsEGFRApoptosisEpidermal growth factor receptorErbB-1HER1EGFR-TKEGFR-TK degradersProteolysis targeting chimeraPROTAC strategyInhibitorinhibitorinhibit

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PROTAC EGFR degrader 6
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