2. Cell Cycle/DNA Damage Stem Cell/Wnt
  3. CDK Casein Kinase
  4. (R)-DRF053 dihydrochloride

(R)-DRF053 dihydrochloride 是一种有效的酪蛋白激酶 1 (CK1)、CDK1/cyclin B 和 CDK5/p25 抑制剂，IC50 分别为 14 nM、220 nM 和 80 nM。(R)-DRF053 dihydrochloride 可防止细胞模型中 CK1 依赖性淀粉样蛋白-β 的产生。

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(R)-DRF053 dihydrochloride Chemical Structure

(R)-DRF053 dihydrochloride Chemical Structure

CAS No. : 1241675-76-2

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(R)-DRF053 dihydrochloride 相关抗体

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

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  • 生物活性

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生物活性

(R)-DRF053 dihydrochloride is a potent casein kinases 1 (CK1), CDK1/cyclin B and CDK5/p25 inhibitor with IC50s of 14 nM, 220 nM and 80 nM, respectively. (R)-DRF053 dihydrochloride prevents the CK1-dependent production of amyloid-beta in a cell model[1].

IC50 & Target[1]

CK1

14 nM (IC50)

CDK1/cyclinB1

220 nM (IC50)

Cdk5/p25

80 nM (IC50)

分子量

490.43

Formula

C23H29Cl2N7O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(R)-DRF053 dihydrochloride 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

(R)-DRF0531241675-76-2CDKCasein KinaseCyclin dependent kinaseCDK1/cyclin BCDK5/p25CK1Inhibitorinhibitorinhibit

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产品名称：
(R)-DRF053 dihydrochloride
目录号：
HY-103383
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