1. 重组蛋白
  2. CD Antigens Receptor Proteins Enzymes & Regulators
  3. Epithelial cell CD Proteins Receptor Tyrosine Kinases Protein Tyrosine Kinases
  4. DDR1/CD167a DDR Family
  5. DDR1
  6. DDR1 蛋白, Rat (HEK293, hFc)

DDR1 蛋白, Rat (HEK293, hFc)

目录号: HY-P75300
产品使用指南

DDR1 蛋白是一种纤维状胶原蛋白受体,可协调关键的细胞过程,包括基质重塑、迁移、分化、存活和增殖。与胶原蛋白结合后,DDR1 激活涉及 SRC 和 MAP 激酶的信号级联,通过 MMP 上调促进基质重塑,促进细胞迁移、伤口愈合和肿瘤侵袭。DDR1 蛋白, Rat (HEK293, hFc) 是重组的 DDR1 蛋白,由 HEK293 表达,带有 C-hFc 标签。DDR1 蛋白, Rat (HEK293, hFc) 全长 413 个氨基酸,分子量约为 ~71 kDa。

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描述

The DDR1 protein is a fibrillar collagen receptor that coordinates key cellular processes including matrix remodeling, migration, differentiation, survival, and proliferation. Upon collagen binding, DDR1 activates signaling cascades involving SRC and MAP kinases, promoting matrix remodeling through MMP upregulation, promoting cell migration, wound healing, and tumor invasion. DDR1 Protein, Rat (HEK293, hFc) is the recombinant rat-derived DDR1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of DDR1 Protein, Rat (HEK293, hFc) is 413 a.a., with molecular weight of ~71 kDa.

研究背景

DDR1 蛋白是一种酪氨酸激酶,作为纤维胶原蛋白的细胞表面受体,协调对组织稳态至关重要的多种细胞过程。它调节细胞与细胞外基质的附着,影响基质重塑、细胞迁移、分化、存活和增殖。胶原蛋白结合后,DDR1 启动涉及 SRC 的信号级联并导致 MAP 激酶激活。这个复杂的网络通过基质金属蛋白酶 MMP2、MMP7 和 MMP9 的上调促进细胞外基质重塑,促进细胞迁移和伤口愈合,并促进肿瘤细胞侵袭。DDR1 的影响通过促进平滑肌细胞迁移延伸至动脉伤口愈合。此外,它使 PTPN11 磷酸化,对于怀孕期间正常囊胚植入、乳腺分化、哺乳以及维持正常耳朵形态和听力是不可或缺的。DDR1 的多功能作用强调了它在控制多种生理过程中的重要性。

种属

Rat

表达系统

HEK293

标签

C-hFc

蛋白编号

Q6MG19 (M1-T413)

基因 ID
蛋白结构
N-term
DDR1 (M1-T413)
Accession # Q6MG19
hFc
C-term
同用名
Epithelial discoidin domain-containing receptor 1; HGK2; CD167a; CAK; EDDR1
分子量

Approximately 71 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
DDR1 Protein, Rat (HEK293, hFc)
目录号:
HY-P75300
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