1. Anti-infection
  2. Bacterial Antibiotic
  3. Sitafloxacin

Sitafloxacin  (Synonyms: 西他沙星; DU6859a)

目录号: HY-B0395
产品使用指南

Sitafloxacin (DU-6859a) 是一种有效的口服活性氟喹诺酮类抗生素。 Sitafloxacin 对广泛的革兰氏阳性和革兰氏阴性细菌 (包括厌氧菌) 以及非典型病原体具有抗菌活性。Sitafloxacin 可用于呼吸道感染和尿路感染的研究。

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Sitafloxacin Chemical Structure

Sitafloxacin Chemical Structure

CAS No. : 127254-12-0

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Sitafloxacin 的其他形式现货产品:

Customer Review

Other Forms of Sitafloxacin:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Sitafloxacin (DU6859a) is a potent, orally active fluoroquinolone antibiotic. Sitafloxacin shows antichlamydial activity and antibacterial activities against a broad range of gram-positive and gram-negative bacteria, including anaerobic bacteria, as well as against atypical pathogens. Sitafloxacin can be used for the research of respiratory tract infection and urinary tract infection[1][2].

IC50 & Target

Quinolone

 

体外研究
(In Vitro)

Sitafloxacin (DU6859a) shows antibacterial activities with MIC of 0.03, 0.12, 0.06 mg/L for wild-type ATCC 49619, gyrA mutant SP39, parC mutant 1026523 streptococcus pneumoniae stran, respectively[1].
Sitafloxacin (DU6859a) shows antibacterial activities for quinolone-susceptible strains of streptococcus pneumoniae with MIC of 0.03, 0.03 mg/L for EG 00093 and EG 00218 strain, respectively[1].
Sitafloxacin (DU6859a) shows inhibition for DNA gyrase and topoisomerase IV (TopoIV) with >IC50s of 4.38, 3.12 mg/L, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Sitafloxacin (DU-6859a) (12.5-100 mg/kg; i.g.; daily for 4 weeks; BALB/c female mice) has antibacterial activity. M. ulcerans cells could be isolated from the inoculated footpads and there was no evidence of footpad swelling[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c female mice[2]
Dosage: 12.5, 25, 50 and 100 mg/kg
Administration: Oral gavage; daily, for 4 weeks
Result: Inhibits the growth of Mycobacterium ulcerans and the M. ulcerans cells.
Clinical Trial
分子量

409.81

Formula

C19H18ClF2N3O3

CAS 号
中文名称

西他沙星;西他富劳克沙欣 西塔沙星

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Sitafloxacin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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